Section 1 - CHEMICAL PRODUCT AND COMPANY IDENTIFICATION

PRODUCT NAME

HUMULONE

NFPA

PRODUCT USE

Antimicrobial isolated from hops. Bittering additive for beverages.

SYNONYMS

C21H30O5, "alpha bitter acid", "alpha lupulic acid", "2, 4-Cyclohexadien-1-one, 3, 5, 6-
trihydroxy-4, 6-bis(3-methyl-2-butenyl)-=", "2, 4-Cyclohexadien-1-one, 3, 5, 6-
trihydroxy-4, 6-bis(3-methyl-2-butenyl)-=", "=-2-(3-methyl-1oxobutyl)-, (R)-, ", "=-2-(3-
methyl-1oxobutyl)-, (R)-, ", "2, 4-Cyclohexadien-1-one, 3, 5, 6-trihydroxy-2-isovaleryl-
4, 6-bis(3 methyl-=", "2, 4-Cyclohexadien-1-one, 3, 5, 6-trihydroxy-2-isovaleryl-4, 6-
bis(3 methyl-=", "=-1-butenyl)-, (R)-(-)", "=-1-butenyl)-, (R)-(-)"

Section 2 - HAZARDS IDENTIFICATION

CANADIAN WHMIS SYMBOLS

None

EMERGENCY OVERVIEW

RISK

POTENTIAL HEALTH EFFECTS

ACUTE HEALTH EFFECTS

SWALLOWED

  Although ingestion is not thought to produce harmful effects, the material may still be damaging to the health of the individual following ingestion, especially where pre-  existing organ (e.g. liver, kidney) damage is evident. Present definitions of harmful or toxic substances are generally based on doses producing mortality (death) rather than those producing morbidity (disease, ill-health). Gastrointestinal tract discomfort may produce nausea and vomiting. In an occupational setting however, ingestion of insignificant quantities is not thought to be cause for concern.  Considered an unlikely route of entry in commercial/industrial environments.  

EYE

  Although the material is not thought to be an irritant, direct contact with the eye may produce transient discomfort characterized by tearing or conjunctival redness (as with windburn).  The material may produce moderate eye irritation leading to inflammation. Repeated or prolonged exposure to irritants may produce conjunctivitis.  

SKIN

  The material is not thought to produce adverse health effects or skin irritation following contact (as classified using animal models). Nevertheless, good hygiene practice requires that exposure be kept to a minimum and that suitable gloves be used in an occupational setting.  Toxic effects may result from skin absorption.  The material may cause skin irritation after prolonged or repeated exposure and may produce on contact skin redness, swelling, the production of vesicles, scaling and thickening of the skin.  

INHALED

  The material is not thought to produce adverse health effects or irritation of the respiratory tract (as classified using animal models). Nevertheless, good hygiene practice requires that exposure be kept to a minimum and that suitable control measures be used in an occupational setting.  Persons with impaired respiratory function, airway diseases and conditions such as emphysema or chronic bronchitis, may incur further disability if excessive concentrations of particulate are inhaled.  

CHRONIC HEALTH EFFECTS

  Principal routes of exposure are usually by skin contact/absorption and inhalation of generated dust.  Daily intragastric administration of lupulon caused slight suppression of  growth in young rats. A slight decrease in weight in rabbits occurred  after 30 mg/kg/day over 14 days. Lupulon, 4% added to the diet, produced  death in 50% of mice within 18 days. Respiratory stimulation was observed  following intravenous injection of lupulon in both anaesthetised and  unanaesthetised animals.  Chin. Y. and H.H. Anderson; Federation Proceedings 8, 281-282, 1949