Section 1 - CHEMICAL PRODUCT AND COMPANY IDENTIFICATION

PRODUCT NAME

JUROX ANAPLEX 5MG TABLETS

NFPA

PRODUCT USE

Anabolic hormone and vitamin complex tablets for use as a supplement in post- surgical
convalescence and geriatrics in dogs and cats

SYNONYMS

MW49687620ENVIRONMEN, 68s

Section 2 - HAZARDS IDENTIFICATION

CANADIAN WHMIS SYMBOLS

EMERGENCY OVERVIEW

RISK

Harmful by inhalation.

POTENTIAL HEALTH EFFECTS

ACUTE HEALTH EFFECTS

SWALLOWED

  Starch has such a low oral acute toxicity that rats given 10-20% of their body weight, show only minimal effects. This may not be true of modified starches but given their use in foods as stabilisers and thickeners, there is probably little cause for concern.  An abnormal craving for starch (amylophagia), during pregnancy, is recognised as a common form of eating disorder in certain localities. In one study the incidence was as high as 35%. Some women retain the habit for years and may ingest several kilograms of starch daily.  Since starch, in such "addicts", accounts for the bulk of the diet, the commonly observed iron-deficiency anaemia is probably the result of the practice and not its cause. Less common complications include parotid gland enlargement and partial intestinal obstruction due to starch concretions (gastroliths). Withdrawal reverse these sequelae.  Polysaccharides are not substantially absorbed from the gastrointestinal tract but may produce a laxative effect. Larger doses may produce intestinal obstruction or stomach concretions.Large quantities of the substituted polysaccharide, methylcellulose (as with other bulk laxatives), may temporarily increase flatulence. Oesophageal obstruction, by swelling, may occur if the material is swallowed dry.Doses of 3-9 gm hydroxypropylcellulose, fed to human subjects, at least one week apart, were eliminated within 96 hours. Animals fed on diets containing 3% or less, experienced no adverse effects. Higher levels produced malnutrition due to excessive bulk but caused no organic damage. In one dog, an oral dose of hydroxypropylcellulose produced diarrhoea and blood cell depression.Ingestion of hetastarch (hydroxyethyl amylopectin) has reportedly produced fever, chills, urticaria and salivary gland enlargement. Several of these effects may be due to contamination by other naturally occurring macromolecules extracted from the source material. Large volumes of ingested hetastarch may interfere with coagulation mechanisms and increase the risk of haemorrhage. Anaphylaxis has occurred.Infusions of dextrans may occasionally produce allergic reactions such as urticaria,hypotension and bronchospasm. Severe anaphylactic reactions may occasionally occurand death may result from cardiac and respiratory arrest. Nausea, vomiting, fever, joint pains, and flushing may also occur. Similarly, allergic reactions, sometimes severe (but rare) have been reported following ingestion or inhalation of tragacanth gums.  

EYE

  Although the material is not thought to be an irritant, direct contact with the eye may produce transient discomfort characterized by tearing or conjunctival redness (as with windburn).  

SKIN

  There is some evidence to suggest that the material may cause mild but significant inflammation of the skin either following direct contact or after a delay of some time. Repeated exposure can cause contact dermatitis which is characterized by redness, swelling and blistering.  Entry into the blood-stream, through, for example, cuts, abrasions or lesions, may produce systemic injury with harmful effects. Examine the skin prior to the use of the material and ensure that any external damage is suitably protected.  The material may cause skin irritation after prolonged or repeated exposure and may produce on contact skin redness, swelling, the production of vesicles, scaling and thickening of the skin.  

INHALED

  The material is not thought to produce adverse health effects or irritation of the respiratory tract (as classified using animal models). Nevertheless, good hygiene practice requires that exposure be kept to a minimum and that suitable control measures be used in an occupational setting.  

CHRONIC HEALTH EFFECTS

  Studies indicate that diets containing large amounts of non-absorbable polysaccharides, such as cellulose, might decrease absorption of calcium, magnesium, zinc and phosphorus.  Some workers may develop chronic occupational dermatitis (generally mild) through the handling of starch products.  When starch is used as a lubricant in surgical gloves, small amounts, released into the patient during the course of surgery, have resulted in granulomas and peritonitis.  There is limited evidence that, skin contact with this product is more likely to cause a sensitization reaction in some persons compared to the general population.  There is some evidence that human exposure to the material may result in developmental toxicity. This evidence is based on animal studies where effects have been observed in the absence of marked maternal toxicity, or at around the same dose levels as other toxic effects but which are not secondary non-specific consequences of the other toxic effects.  Exposure to the material for prolonged periods may cause physical defects in the developing embryo (teratogenesis).  Prolonged use of Vitamin C is associated with formation of kidneystones in some persons.  Prolonged overdose of Vitamin A is associated with fatigue, irritability, loss of weight and appetite, mild fever, increased amounts of urine, enlarged liver and spleen, hair loss, bleeding lips, thickening of skin and yellow pigmentation. Bone and joint pain may occur, and growth may be permanently arrested in children. There may be birth defects and loss of bone mineral associated with carotenoids.