NALOXONE METHYL BROMIDE
Flammability | 1 | |
Toxicity | 2 | |
Body Contact | 0 | |
Reactivity | 1 | |
Chronic | 0 | |
SCALE: Min/Nil=0 Low=1 Moderate=2 High=3 Extreme=4 |
Used as a specific opiate antagonist. Medicine
C20-H24-N-O4.Br, C20-H24-N-O4.Br, "naloxone methobromidemethyl bromide of:", "4, 5-epoxy-
3, 14-dihydroxy-17-(2-propenyl)-morphinan-6-one", "4, 5-epoxy-3, 14-dihydroxy-17-(2-
propenyl)-morphinan-6-one", "(5-alpha)-4, 5-epoxy-3, 14-dihydroxy-17-(2-propenyl)-
morphinan-6-one", "(5-alpha)-4, 5-epoxy-3, 14-dihydroxy-17-(2-propenyl)-morphinan-6-one",
"morphinan-6-one, 4, 5alpha-epoxy-3, 14-dihydroxy-17(2-propenyl)", "morphinan-6-one, 4,
5alpha-epoxy-3, 14-dihydroxy-17(2-propenyl)", 5alpha-, "17-allyl-4, 5-alpha-epoxy-3, 14-
dihydroxymorphinan-6-one", "17-allyl-4, 5-alpha-epoxy-3, 14-dihydroxymorphinan-6-one", 1-
N-allyl-14-hydroxynordihydromorphinone, 1-N-allyl-14-hydroxynordihydromorphinone, "(-)-N-
allyl-7, 8-dihydro-14-hydroxy-normorphinone", "(-)-N-allyl-7, 8-dihydro-14-hydroxy-
normorphinone", "normorphinone, N-allyl-7, 8-dihydro-14-hydroxy-, (-)-", "normorphinone,
N-allyl-7, 8-dihydro-14-hydroxy-, (-)-", l-naloxone, l-naloxone, "12-allyl-7, 7a, 8, 9-
tetrahydro-3, 7a-dihydroxy-", "12-allyl-7, 7a, 8, 9-tetrahydro-3, 7a-dihydroxy-", "4aH-8,
9c-iminoethanophenanthro[4, 5-bcd]furanone", N-allylnoroxymorphine, N-allylnoroxymorphine,
normorphinone, "narcotic antagonist"
None
Although ingestion is not thought to produce harmful effects, the material may still be damaging to the health of the individual following ingestion, especially where pre- existing organ (e.g. liver, kidney) damage is evident. Present definitions of harmful or toxic substances are generally based on doses producing mortality (death) rather than those producing morbidity (disease, ill-health). Gastrointestinal tract discomfort may produce nausea and vomiting. In an occupational setting however, ingestion of insignificant quantities is not thought to be cause for concern. Accidental ingestion of the material may be damaging to the health of the individual. Morphine and other analgesics cause nausea, vomiting, constipation, drowsiness and confusion. Urination can be difficult, and the bowel and bile ducts can spasm. They also cause dry mouth, pin point pupils, sweating, flushing, vertigo, slow and shallow breathing, weak pulse, blue-gray skin (cyanosis), palpitations, low blood pressure, low temperature, restlessness, and mood changes. Acute toxic effects include lung swelling, spasticity, muscle twitching and unconsciousness. Increased pressure in the head may occur. Larger doses can cause depression of breathing and low blood pressure, with failure of circulation and deepening coma. Failure of breathing can cause death. As the analgesia (loss of sensation) wears off, sensitivity to pain is increased. Higher doses produce stiffening of the muscles and depression of the central nervous system; this can progress to stupor, sedation, unconsciousness and coma. The blood vessels may dilate, causing flushing of the face, neck and upper chest, and lowering of the blood pressure, resulting in fainting. Serious effects due to toxicity to the heart include high blood pressure, irregular heart rhythms, shock, acute heart failure and stoppage. Hypersensitive reactions can occur, producing rashes, itch, bleeding, and blistering. Digestive effects include constipation, impaction of the bowel with feces and cramps. Urine movements may become less frequent. There may be liver abnormalities, and the liver may be enlarged and tender to touch.
Although the material is not thought to be an irritant, direct contact with the eye may cause transient discomfort characterized by tearing or conjunctival redness (as with windburn). Slight abrasive damage may also result. The material may produce foreign body irritation in certain individuals.
The material is not thought to produce adverse health effects or skin irritation following contact (as classified using animal models). Nevertheless, good hygiene practice requires that exposure be kept to a minimum and that suitable gloves be used in an occupational setting. Entry into the blood-stream, through, for example, cuts, abrasions or lesions, may produce systemic injury with harmful effects. Examine the skin prior to the use of the material and ensure that any external damage is suitably protected.
The material is not thought to produce either adverse health effects or irritation of the respiratory tract following inhalation (as classified using animal models). Nevertheless, adverse effects have been produced following exposure of animals by at least one other route and good hygiene practice requires that exposure be kept to a minimum and that suitable control measures be used in an occupational setting.
Long term exposure to high dust concentrations may cause changes in lung function i.e. pneumoconiosis; caused by particles less than 0.5 micron penetrating and remaining in the lung. Prime symptom is breathlessness; lung shadows show on X-ray. Long-term exposure to the product is not thought to produce chronic effects adverse to the health (as classified using animal models); nevertheless exposure by all routes should be minimized as a matter of course.