HAEMATOPORPHYRIN IX DIMETHYL ESTER
Flammability | 1 | |
Toxicity | 1 | |
Body Contact | 2 | |
Reactivity | 0 | |
Chronic | 0 | |
SCALE: Min/Nil=0 Low=1 Moderate=2 High=3 Extreme=4 |
Haematoporphyrins have been used in the treatment of anaemia, debility and depressive
states.
C36-H42-N4-O6, "21H, 23H-porphine-2, 18-dipropanoic acid, 7, 12-bis(1-hydroxyethyl)-3, 8,
13, 17-tetramethyl-, dimethyl ester", "21H, 23H-porphine-2, 18-dipropanoic acid, 7, 12-
bis(1-hydroxyethyl)-3, 8, 13, 17-tetramethyl-, dimethyl ester", "2, 18-
porphinedipropanoic acid, 7, 12-bis(1-hydroxyethyl)-3, 8, 13, 17-tetramethyl-, dimethyl
ester", "2, 18-porphinedipropanoic acid, 7, 12-bis(1-hydroxyethyl)-3, 8, 13, 17-
tetramethyl-, dimethyl ester", "hematoporphyrin IX dimethyl ester", "hematoporphyrin IX
dimethyl ester"
None
Although ingestion is not thought to produce harmful effects, the material may still be damaging to the health of the individual following ingestion, especially where pre- existing organ (e.g. liver, kidney) damage is evident. Present definitions of harmful or toxic substances are generally based on doses producing mortality (death) rather than those producing morbidity (disease, ill-health). Gastrointestinal tract discomfort may produce nausea and vomiting. In an occupational setting however, ingestion of insignificant quantities is not thought to be cause for concern. Considered an unlikely route of entry in commercial/industrial environments.
Although the material is not thought to be an irritant, direct contact with the eye may produce transient discomfort characterized by tearing or conjunctival redness (as with windburn).
The material is not thought to produce adverse health effects or skin irritation following contact (as classified using animal models). Nevertheless, good hygiene practice requires that exposure be kept to a minimum and that suitable gloves be used in an occupational setting. Exposure to this product can cause sensitization of skin under sunlight. The product can reach the skin via the bloodstream either if swallowed or ingested. Swelling and redness are common; blistering may also occur. The skin may become warm and itchy. There may also be discoloration. Phototoxicity is a non-allergic condition and severity depends on the concentration of the offending chemical and the amount of radiation of particular wavelengths, usually in the UV spectrum. Inflammation develops on uncovered areas such as the hands and face; covered areas are usually spared. This is usually more like sunburn than an eczema. Coal tar products often cause phototoxic reactions. Phototoxic compounds may show their nature either by generating free radicals or reacting directly with target molecules under UV light.
The material is not thought to produce adverse health effects or irritation of the respiratory tract (as classified using animal models). Nevertheless, good hygiene practice requires that exposure be kept to a minimum and that suitable control measures be used in an occupational setting. Persons with impaired respiratory function, airway diseases and conditions such as emphysema or chronic bronchitis, may incur further disability if excessive concentrations of particulate are inhaled.
Principal routes of exposure are usually by skin contact/absorption and inhalation of generated dust. Photosensitisation has been reported after intravenous administration of haematoporphyrin IX.