LEVODOPA-D3
Flammability | 1 | |
Toxicity | 1 | |
Body Contact | 1 | |
Reactivity | 0 | |
Chronic | 0 | |
SCALE: Min/Nil=0 Low=1 Moderate=2 High=3 Extreme=4 |
Deuteriated derivative of a naturally occurring amino- acid. Levodopa is a precursor of
the synaptic neurotransmitter, dopamine. In contrast to dopamine, levodopa readily enters
the central nervous system and as a result is used in the treatment of conditions such as
Parkinson' s disease. Also used to control the neurological symptoms of chronic manganese
poisoning which resembles Parkinsonism. Normally given by mouth.
C9-H8-D3-N-O4, C9-H8-D3-N-O4, "levadopa-D3 (sic)", L-dihydroxyphenylalanine-D3, L-
dihydroxyphenylalanine-D3, (-)-dopa-D3, L-O-hydroxytyrosine-D3, L-O-hydroxytyrosine-D3, L-
dopa-D3, L-dopa-D3, L-dopa-ring-D3, L-dopa-ring-D3, "dopaminergic amino-acid"
None
Although ingestion is not thought to produce harmful effects, the material may still be damaging to the health of the individual following ingestion, especially where pre- existing organ (e.g. liver, kidney) damage is evident. Present definitions of harmful or toxic substances are generally based on doses producing mortality (death) rather than those producing morbidity (disease, ill-health). Gastrointestinal tract discomfort may produce nausea and vomiting. In an occupational setting however, ingestion of insignificant quantities is not thought to be cause for concern.
Although the material is not thought to be an irritant, direct contact with the eye may produce transient discomfort characterized by tearing or conjunctival redness (as with windburn). The dust may produce eye discomfort causing smarting, pain and redness.
The material is not thought to produce adverse health effects or skin irritation following contact (as classified using animal models). Nevertheless, good hygiene practice requires that exposure be kept to a minimum and that suitable gloves be used in an occupational setting. Open cuts, abraded or irritated skin should not be exposed to this material.
The material is not thought to produce adverse health effects or irritation of the respiratory tract (as classified using animal models). Nevertheless, good hygiene practice requires that exposure be kept to a minimum and that suitable control measures be used in an occupational setting. Persons with impaired respiratory function, airway diseases and conditions such as emphysema or chronic bronchitis, may incur further disability if excessive concentrations of particulate are inhaled.
Principal routes of exposure are by accidental skin and eye contact andinhalation of generated dusts. Chronic exposure in humans produces somnolence, hallucinations and distorted perceptions, toxic psychosis, ataxia, tetany, and changes in motor activity. Skin tumours developed in one patient exposed to levodopa for 18 months. Oral administration during days 1-22 of pregnancy in rats, produced foetal developmental abnormalities. Effects on fertility may also occur.