Section 1 - CHEMICAL PRODUCT AND COMPANY IDENTIFICATION

PRODUCT NAME

O-AMINOPYRIDINE

NFPA

PRODUCT USE

Manufacture of pharmaceuticals especially antihistamines. Regeant

SYNONYMS

C5-H6-N2, H2NC5H4N, alpha-aminopyridine, 2-pyridinamine, 2-pyridinamine, amino-2-pyridine,
amino-2-pyridine, alpha-pyridinamine, alpha-pyridylamine, 2-pyridylamine, 2-pyridylamine,
"o aminopyridine", "amino 2 pyridine", "2 aminopyridine", "alpha pyridinamine"

Section 2 - HAZARDS IDENTIFICATION

CANADIAN WHMIS SYMBOLS

EMERGENCY OVERVIEW

RISK

Harmful in contact with skin.
Toxic if swallowed.
Irritating to eyes, respiratory system and skin.

POTENTIAL HEALTH EFFECTS

ACUTE HEALTH EFFECTS

SWALLOWED

  Toxic effects may result from the accidental ingestion of the material; animal experiments indicate that ingestion of less than 40 gram may be fatal or may produce serious damage to the health of the individual.  

EYE

  This material can cause eye irritation and damage in some persons.  

SKIN

  Skin contact with the material may be harmful; systemic effects may resultfollowing absorption.  This material can cause inflammation of the skin oncontact in some persons.  The material may accentuate any pre-existing dermatitis condition.  Open cuts, abraded or irritated skin should not be exposed to this material.  Entry into the blood-stream, through, for example, cuts, abrasions or lesions, may produce systemic injury with harmful effects. Examine the skin prior to the use of the material and ensure that any external damage is suitably protected.  

INHALED

  The material can cause respiratory irritation in some persons. The body's response to such irritation can cause further lung damage.  Inhalation of vapors or aerosols (mists, fumes), generated by the material during the course of normal handling, may produce serious damage to the health of the individual.  Inhalation hazard is increased at higher temperatures.  Persons with impaired respiratory function, airway diseases and conditions such as emphysema or chronic bronchitis, may incur further disability if excessive concentrations of particulate are inhaled.  

CHRONIC HEALTH EFFECTS

  Long-term exposure to respiratory irritants may result in disease of the airways involving difficult breathing and related systemic problems.  There has been some concern that this material can cause cancer or mutations but there is not enough data to make an assessment.  Limited evidence suggests that repeated or long-term occupational exposure may produce cumulative health effects involving organs or biochemical systems.  There is limited evidence that, skin contact with this product is more likely to cause a sensitization reaction in some persons compared to the general population.  Long term exposure to high dust concentrations may cause changes in lung function i.e. pneumoconiosis; caused by particles less than 0.5 micron penetrating and remaining in the lung. Prime symptom is breathlessness; lung shadows show on X-ray.  Data from experimental studies indicate that pyridines represent a potential cause of cancer in man. They have also been shown to cross the placental barrier in rats and cause premature delivery, miscarriages and stillbirths. PAs are passed through breast milk. Pyridine has been implicated in the formation of liver cancers.