Section 1 - CHEMICAL PRODUCT AND COMPANY IDENTIFICATION

PRODUCT NAME

VIRBAC FLUKARE C WITH SELENIUM

NFPA

PRODUCT USE

Flukicide for the treatment of cattle sheep and goats. For the treatment of susceptible
Early Immature, Immature, and Mature liver fluke (Fasciola hepatica) in cattle sheep and
goats. And in aid of controlling selenium deficiencies.

SYNONYMS

Virbac, "Flukicide Flucicide Flukiside"

Section 2 - HAZARDS IDENTIFICATION

CANADIAN WHMIS SYMBOLS

EMERGENCY OVERVIEW

RISK

Danger of cumulative effects.
Harmful by inhalation, in contact with skin and if swallowed.
Harmful to aquatic organisms, may cause long- term adverse effects in the
aquatic environment.

POTENTIAL HEALTH EFFECTS

ACUTE HEALTH EFFECTS

SWALLOWED

  Accidental ingestion of the material may be harmful; animal experiments indicate that ingestion of less than 150 gram may be fatal or may produce serious damage to the health of the individual.  There is some evidence to suggest that this material can cause, if swallowed once, irreversible damage of organs.  Chlorphenoxy compounds irritate the digestive system and cause nausea and vomiting, chest pain, and diarrhea. Taking large doses can result in mineral imbalance, temperature changes, hyperventilation, low blood pressure, dilated blood vessels, damage to the heart and liver with death of white blood cells, and convulsions. Most salts and esters of 2,4-  D exhibit similar effects, although the free acid is more toxic. Massive doses can cause ventricular fibrillation followed by death. If death is delayed, there may be a sluggishness followed by spastic changes in muscles and inco-ordination. Severe cases cause apathy, weakness in the legs, regular muscle spasms and coma. Subacute poisonings cause severe nosebleeds, bleeding from the mouth and irritation of the eye and nose. Clinically, poisonings are uncommon, although muscle weakness and nervous symptoms in the extremities are sometimes reported. The substances are not metabolized and are excreted only slowly from the body, in the urine.  Benzimidazole carbamate anthelmintics, when administered in therapeutic doses, have produced allergic reaction (which may be associated with destruction of parasites), raised liver enzyme values,and may be associated with leukopenia and alopecia. Extremely large oral doses may produce intestinal cramps, anorexia, lethargy, pulmonary haemorrhage,  oedema, hepatic and epicardial haemorrhage, and nausea, vomiting and diarrhoea. Other symptoms include dizziness, giddiness, tinnitus, insomnia, anxiety, confusion, convulsions, hallucinations and headache. Overdose may produce gastrointestinal symptoms, visual disturbance and psychic alterations. Absorption is generally limited.  Animal studies suggest that this family of drugs may also be teratogenic.  Central nervous system (CNS) depression may include general discomfort, symptoms of giddiness, headache, dizziness, nausea, anaesthetic effects, slowed reaction time, slurred speech and may progress to unconsciousness. Serious poisonings may result in respiratory depression and may be fatal.  

EYE

  Although the liquid is not thought to be an irritant, direct contact with the eye may produce transient discomfort characterized by tearing or conjunctival redness (as with windburn).  

SKIN

  Skin contact with the material may be harmful; systemic effects may resultfollowing absorption.  The material is not thought to be a skin irritant (as classified using animal models). Temporary discomfort, however, may result from prolonged dermal exposures. Good hygiene practice requires that exposure be kept to a minimum and that suitable gloves be used in an occupational setting.  Entry into the blood-stream, through, for example, cuts, abrasions or lesions, may produce systemic injury with harmful effects. Examine the skin prior to the use of the material and ensure that any external damage is suitably protected.  Toxic effects may result from skin absorption.  Exposure limits with "skin" notation indicate that vapor and liquid may be absorbed through intact skin. Absorption by skin may readily exceed vapor inhalation exposure. Symptoms for skin absorption are the same as for inhalation. Contact with eyes and mucous membranes may also contribute to overall exposure and may also invalidate the exposure standard.  

INHALED

  Inhalation of vapors or aerosols (mists, fumes), generated by the material during the course of normal handling, may be harmful.  Not normally a hazard due to non-volatile nature of product.  The material is not thought to produce respiratory irritation (as classified using animal models). Nevertheless inhalation of vapors, fumes or aerosols, especially for prolonged periods, may produce respiratory discomfort and occasionally, distress.  Inhalation of chlorophenoxy dusts or mists may result in sore throat, burning sensations in the throat and chest, cough, tears, inflamed nose, dizziness and inco-ordination, as a result of absorption from the lungs.  

CHRONIC HEALTH EFFECTS

  Repeated or long-term occupational exposure is likely to produce cumulative health effects involving organs or biochemical systems.  There has been some concern that this material can cause cancer or mutations but there is not enough data to make an assessment.  There is some evidence that inhaling this product is more likely to cause a sensitization reaction in some persons compared to the general population.  There is limited evidence that, skin contact with this product is more likely to cause a sensitization reaction in some persons compared to the general population.  Benzimidazole carbamate anthelmintics, when administered in therapeutic doses, have produced allergic reaction (which may be associated with destruction of parasites), raised liver enzyme values,and may be associated with leukopenia and alopecia. Extremely large oral doses may produce intestinal cramps, anorexia, lethargy, pulmonary haemorrhage,  oedema, hepatic and epicardial haemorrhage, and nausea, vomiting and diarrhoea. Other symptoms include dizziness, giddiness, tinnitus, insomnia, anxiety, confusion, convulsions, hallucinations and headache. Overdose may produce gastrointestinal symptoms, visual disturbance and psychic alterations. Absorption is generally limited.  Animal studies suggest that this family of drugs may also be teratogenic.  Chlorophenoxy herbicides cause an increased risk of cancers of soft tissue, lymph and bronchi. Inflammation of skin can result from long term contact. Chronic exposure to 2,4-  D can cause nausea, liver changes, skin eruptions, irritation of the airways and eyes, as well as nervous changes. People with chronic health conditions or who have endocrinological or immune disorders should not be exposed to herbicides.  Sodium phosphate dibasic can cause stones in the kidney, loss of mineral from the bones and loss of thyroid gland function.