UVASORB K2A
Flammability | 1 | |
Toxicity | 0 | |
Body Contact | 0 | |
Reactivity | 1 | |
Chronic | 2 | |
SCALE: Min/Nil=0 Low=1 Moderate=2 High=3 Extreme=4 |
Sunscreen Medicine
C47-H56-N8-O3, "2, 4-bis-[4-[5-(1, 1-dimethyl-propyl)benzoxazol-2-yl]phenylimino]-6-[(2-
ethylexyl)imino]-1, 3, 5-triazin", "2, 4-bis-[4-[5-(1, 1-dimethyl-propyl)benzoxazol-2-
yl]phenylimino]-6-[(2-ethylexyl)imino]-1, 3, 5-triazin", ZN3044, "benzoxazole derivative",
"secondary amine", "UV sunscreen"
The material has NOT been classified as "harmful by ingestion". This is because of the lack of corroborating animal or human evidence. The material may still be damaging to the health of the individual, following ingestion, especially where pre-existing organ (e.g. liver, kidney) damage is evident. Present definitions of harmful or toxic substances are generally based on doses producing mortality (death) rather than those producing morbidity (disease, ill-health). Gastrointestinal tract discomfort may produce nausea and vomiting. In an occupational setting however, unintentional ingestion is not thought to be cause for concern.
Although the material is not thought to be an irritant, direct contact with the eye may cause transient discomfort characterized by tearing or conjunctival redness (as with windburn). Slight abrasive damage may also result. The material may produce foreign body irritation in certain individuals.
The material is not thought to produce adverse health effects or skin irritation following contact (as classified using animal models). Nevertheless, good hygiene practice requires that exposure be kept to a minimum and that suitable gloves be used in an occupational setting. Entry into the blood-stream, through, for example, cuts, abrasions or lesions, may produce systemic injury with harmful effects. Examine the skin prior to the use of the material and ensure that any external damage is suitably protected.
The material is not thought to produce adverse health effects or irritation of the respiratory tract (as classified using animal models). Nevertheless, good hygiene practice requires that exposure be kept to a minimum and that suitable control measures be used in an occupational setting.
There has been some concern that this material can cause cancer or mutations but there is not enough data to make an assessment. Compounds found to be photogenotoxic can be considered as potential photocarcinogens and a specific testing in rodent photocarcinogenicity studies is normally not required? After a positive photogenotoxicity test, photocarcinogenic potential is assumed, otherwise photocarcinogenicity testing is required. In vivo testing for photochemical genotoxicity is problematic since the skin cannot be easily utilized in standard approaches. Transgenic mutagenicity models may be useful in this area in that they allow determination of mutations in skin cells.?The psoralens and uroquinolones, that have been tested for photochemical carcinogenesis and have produced positive results, are photochemical genotoxins. Hence, the correlation of experimental data between photochemical carcinogens and photochemical genotoxins is convincing. Long term exposure to high dust concentrations may cause changes in lung function i.e. pneumoconiosis; caused by particles less than 0.5 micron penetrating and remaining in the lung. Prime symptom is breathlessness; lung shadows show on X-ray. Speculative discussion surrounds the use of sunscreens and a possible rise in the incidence of melanoma. One mechanism proposed involves the development of free radicals following UVB absorption by the chemical agent; free radicals are potentially damaging to DNA. A further mechanism involves the inhibition of Vitamin D production; low levels of Vitamin D have been associated with an increased risk of the development of breast and colon cancer and may also accelerate the growth of melanoma. (UVASORB K2A) belongs to the class of secondary amines and thus it is prone to nitrosation