Section 1 - CHEMICAL PRODUCT AND COMPANY IDENTIFICATION

PRODUCT NAME

P-ISOPROPENYLPHENOL

NFPA

PRODUCT USE

Photo- resist

SYNONYMS

C9-H10-O, HOC6H4C(CH3)=CH2, 4-(1-methylethenyl)phenol, 4-(1-methylethenyl)phenol, "Milex
PM", "alkyl phenol", photoresist

Section 2 - HAZARDS IDENTIFICATION

CANADIAN WHMIS SYMBOLS

EMERGENCY OVERVIEW

RISK

Harmful if swallowed.

POTENTIAL HEALTH EFFECTS

ACUTE HEALTH EFFECTS

SWALLOWED

  Accidental ingestion of the material may be harmful; animal experiments indicate that ingestion of less than 150 gram may be fatal or may produce serious damage to the health of the individual.  Limited evidence exists that the substance may cause irreversible but non-lethal mutagenic effects following a single exposure.  Some phenol derivatives can cause damage to the digestive system. If absorbed, profuse sweating, thirst, nausea, vomiting diarrhea, cyanosis, restlessness, stupor, low blood pressure, gasping, abdominal pain, anemia, convulsions, coma and lung swelling can happen followed by pneumonia. There may be respiratory failure and kidney damage. Chemical burns,  seizures and irregular heartbeat may result.  

EYE

  There is some evidence to suggest that this material can causeeye irritation and damage in some persons.  Some phenol derivatives may produce mild to severe eye irritation with redness, pain and blurred vision. Permanent eye injury may occur; recovery may also be complete or partial.  

SKIN

  Skin contact with the material may damage the health of the individual; systemic effects may result following absorption.  There is some evidence to suggest that this material can cause inflammation of the skin on contact in some persons.  Phenol and its derivatives can cause severe skin irritation if contact is maintained, and can be absorbed to the skin affecting the cardiovascular and central nervous system. Effects include sweating, intense thirst, nausea and vomiting, diarrhea, cyanosis, restlessness, stupor, low blood pressure, hyperventilation, abdominal pain, anemia, convulsions, coma, lung swelling followed by pneumonia. Respiratory failure and kidney damage may follow.  Entry into the blood-stream, through, for example, cuts, abrasions or lesions, may produce systemic injury with harmful effects. Examine the skin prior to the use of the material and ensure that any external damage is suitably protected.  

INHALED

  Inhalation may produce health damage*.  Inhalation of vapors or aerosols (mists, fumes), generated by the material during the course of normal handling, may be damaging to the health of the individual.  There is some evidence to suggest that the material can cause respiratory irritation in some persons. The body's response to such irritation can cause further lung damage.  If phenols are absorbed via the lungs, systemic effects may occur affecting the cardiovascular and nervous systems. Inhalation can result in profuse perspiration, intense thirst, nausea, vomiting, diarrhea, cyanosis, restlessness, stupor, falling blood pressure, hyperventilation, abdominal pain, anemia, convulsions, coma, swelling and inflammation of the lung. This is followed by respiratory failure and kidney damage. Phenols also cause loss of sensation and general depression at high concentrations. The toxicities of phenol derivatives vary.  

CHRONIC HEALTH EFFECTS

  Long-term exposure to phenol derivatives can cause skin inflammation, loss of appetite and weight, weakness, muscle aches and pain, liver damage, dark urine, loss of nails, skin eruptions, diarrhea, nervous disorders with headache, salivation, fainting, discoloration of the skin and eyes, vertigo and mental disorders, and damage to the liver and kidneys.  Limited evidence suggests that repeated or long-term occupational exposure may produce cumulative health effects involving organs or biochemical systems.  Exposure to the material may cause concerns for human fertility, on the basis that similar materials provide some evidence of impaired fertility in the absence of toxic effects, or evidence of impaired fertility occurring at around the same dose levels as other toxic effects, but which are not a secondary non-specific consequence of other toxic effects..  Exposure to the material may result in a possible risk of irreversible effects. The material may produce mutagenic effects in man. This concern is raised, generally, on the basis ofappropriate studies with similar materials using mammalian somatic cells in vivo. Such findings are often supported by positive results from in vitro mutagenicity studies.  Exposure to alkyl phenolics  is associated with reduced sperm count andfertility in males.  A preliminary reproduction toxicity screening test was conducted at doses of 0,  4, 15 and 60 mg/kg in rats following OECD test guideline 421. Transient  salivation occurred after oral administration in the group receiving 60 mg/kg.  Thickening of mucosa of forestomach due to squamous hyperplasia was observed in  the 60 mg/kg group at autopsy. A decrease in the thymus weight was observed in  females of the 60 mg/kg group. There were no adverse effects on any reproductive  and developmental parameters. The no observed effect dose level (NOEL) for  systemic toxicity was considered to be 15 mg/kg/day in both sexes, and that for  reproductive and developmental toxicity was 60 mg/kg/day.  Reverse mutation assays using microorganisms (Salmonella typhimurium,  Escherichia coli) were conducted to assess the potential of he substance to  induce gene mutations.  The substance did not induce gene mutations in bacteria under the conditions of  this study.  In vitro chromosomal aberration tests using cultured Chinese hamster cells  (CHL/IU) were conducted to assess the potential of the substance to induce  chromosomal aberrations.  The substance induced chromosomal aberrations in cultured cells under the  conditions of this study.