SABELUZOLE
Flammability | 1 | |
Toxicity | 3 | |
Body Contact | 1 | |
Reactivity | 1 | |
Chronic | 0 | |
SCALE: Min/Nil=0 Low=1 Moderate=2 High=3 Extreme=4 |
Nootropic.
C22-H26-F-N3-O2-S, (+/-)-4-(2-benzothiazolylmethylamino)-alpha-[(4-fluorophenoxy)methyl]-
1-piperidineethanol, (+/-)-4-(2-benzothiazolylmethylamino)-alpha-[(4-
fluorophenoxy)methyl]-1-piperidineethanol, N-methyl-N-[1-(3-(4-fluorophenoxy)-
2hydroxypropyl)piperidin-4-yl]benzothiazole-2-amine, N-methyl-N-[1-(3-(4-fluorophenoxy)-
2hydroxypropyl)piperidin-4-yl]benzothiazole-2-amine, R-58735, R-58735, Reminyl, nootoropic
Toxic if swallowed.
Toxic effects may result from the accidental ingestion of the material; animal experiments indicate that ingestion of less than 40 gram may be fatal or may produce serious damage to the health of the individual. The main features defining a nootropic drugs are: the enhancement of learning and memory acquisition · Protection of the brain against various physical or chemical injury · Facilitation of flow of information between the hemispheres of the brain · Absence of usual negative effects of psychotropic drugs particularly central nervous system toxicity. Extensive study of the modes of action of the nootropics reveals certain pharmacological effects There appears to be no single predominant mode of action shared by the whole class of drugs, however all influence cholinergic function. By increasing high affinity choline uptake these drugs facilitate acetylcholine production and turnover with various actions at both muscarinic and nicotinic receptors (there is a serious decline in acetylcholine reception in aged humans). Occasional side-effects may include nausea, vomiting, headache, blurred vision, skin rashes, nasal stuffiness, flushing of the skin, dizziness, bradycardia and orthostatic hypotension. Cardiovascular effects may include sinus bradycardia.
There is some evidence to suggest that this material can causeeye irritation and damage in some persons. Although the material is not thought to be an irritant, direct contact with the eye may cause transient discomfort characterized by tearing or conjunctival redness (as with windburn). Slight abrasive damage may also result. The material may produce foreign body irritation in certain individuals.
Skin contact is not thought to produce harmful health effects (as classified using animal models). Systemic harm, however, has been identified following exposure of animals by at least one other route and the material may still produce health damage following entry through wounds, lesions or abrasions. Good hygiene practice requires that exposure be kept to a minimum and that suitable gloves be used in an occupational setting. Entry into the blood-stream, through, for example, cuts, abrasions or lesions, may produce systemic injury with harmful effects. Examine the skin prior to the use of the material and ensure that any external damage is suitably protected.
There is some evidence to suggest that this material, if inhaled, can irritate the throat and lungs of some persons. Although inhalation is not thought to produce harmful effects, the material may still produce health damage, especially where pre-existing organ (e.g. liver, kidney) damage is evident. Present definitions of harmful or toxic substances are generally confined to doses producing mortality (death) rather than those producing morbidity (disease, ill- health).
Long term exposure to high dust concentrations may cause changes in lung function i.e. pneumoconiosis; caused by particles less than 0.5 micron penetrating and remaining in the lung. Prime symptom is breathlessness; lung shadows show on X-ray. Long-term exposure to the product is not thought to produce chronic effects adverse to the health (as classified using animal models); nevertheless exposure by all routes should be minimized as a matter of course. In a 3-month rat study doses of up to 40 mg/100 gm feed produced no toxic effects with the exception of weight loss at 10 and 40 mg. In dogs a similar, but more pronounced weight loss was observed at 40 mg/kg/day (orally), while doses of 2.5 and 10 mg/kg b.w. were atoxic There were no direct effect on fertility in rats. Rat and rabbit studies do not show primary harmful effects on the foetus. Only at maternally toxic doses (equal to or exceeding 40 mg/kg) were mild, secondary effects observed on the pups