|SCALE: Min/Nil=0 Low=1 Moderate=2 High=3 Extreme=4|
Antibiotic substance belonging to a family which includes gliotoxin, sporidesmin,
aranotin, and chaetocin. Produced by a species of Verticillium, an imperfect fungus
isolated from a basidiocarp of Coltricia cinnamomea (Polystictus cinnamomeus).
C30-H28-N6-O7-S5, "chaetocin, 19, 19-dideoxy-6, 6'-dihydroxy-mono-3-hydroxymethyl-",
"chaetocin, 19, 19-dideoxy-6, 6'-dihydroxy-mono-3-hydroxymethyl-", "chetocin, 19, 19-
dideoxy-6, 6'-dihydroxy-mono-3-hydroxymethyl-", "chetocin, 19, 19-dideoxy-6, 6'-
dihydroxy-mono-3-hydroxymethyl-", "(6S, 6'S)-19, 19'-dideoxy-6, 6'-mono-3-
hydroxymethyldihydroxychetocin", "(6S, 6'S)-19, 19'-dideoxy-6, 6'-mono-3-
hydroxymethyldihydroxychetocin", "mono-3-hydroxymethyl-verticillin A", "mono-3-
hydroxymethyl-verticillin A", "3, 6-epidithio-2, 5-dioxopiperazine antibacterial/
antibiotic mycotoxin", "3, 6-epidithio-2, 5-dioxopiperazine antibacterial/ antibiotic
Although ingestion is not thought to produce harmful effects, the material may still be damaging to the health of the individual following ingestion, especially where pre- existing organ (e.g. liver, kidney) damage is evident. Present definitions of harmful or toxic substances are generally based on doses producing mortality (death) rather than those producing morbidity (disease, ill-health). Gastrointestinal tract discomfort may produce nausea and vomiting. In an occupational setting however, ingestion of insignificant quantities is not thought to be cause for concern. Considered an unlikely route of entry in commercial/industrial environments. This material contains a fungal toxin. Sporidesmin A can cause facial eczema in and high levels of bile enzymes. The toxic syndrome is probably less important in humans.
Although the material is not thought to be an irritant, direct contact with the eye may produce transient discomfort characterized by tearing or conjunctival redness (as with windburn).
Skin contact with the material may damage the health of the individual; systemic effects may result following absorption. The material is not thought to be a skin irritant (as classified using animal models). Temporary discomfort, however, may result from prolonged dermal exposures. Good hygiene practice requires that exposure be kept to a minimum and that suitable gloves be used in an occupational setting. Toxic effects may result from skin absorption. Entry into the blood-stream, through, for example, cuts, abrasions or lesions, may produce systemic injury with harmful effects. Examine the skin prior to the use of the material and ensure that any external damage is suitably protected.
Inhalation may produce health damage*. The material is not thought to produce respiratory irritation (as classified using animal models). Nevertheless inhalation of the material, especially for prolonged periods, may produce respiratory discomfort and occasionally, distress. Persons with impaired respiratory function, airway diseases and conditions such as emphysema or chronic bronchitis, may incur further disability if excessive concentrations of particulate are inhaled.
Principal routes of exposure are usually by skin contact/absorption and inhalation of generated dust. Treatment with sporidesmin A has produced some genetic aberrations and mutations. These effects are probably due to the production of free radicals.