Section 1 - CHEMICAL PRODUCT AND COMPANY IDENTIFICATION

PRODUCT NAME

HB FULLER ROOF GUTTER AND CONCRETE SILICONE SEALANT - GREY

NFPA

PRODUCT USE

Sealant used in the building industry. Apply directly from the cartridge using a caulking
gun.

SYNONYMS

"silicone sealant, trade roof gutter and concrete silicone sealant"

Section 2 - HAZARDS IDENTIFICATION

CANADIAN WHMIS SYMBOLS

EMERGENCY OVERVIEW

RISK

Contact with water liberates extremely flammable gases.
May form explosive peroxides.
Irritating to eyes.
May cause SENSITIZATION by skin contact.
Limited evidence of a carcinogenic effect.

POTENTIAL HEALTH EFFECTS

ACUTE HEALTH EFFECTS

SWALLOWED

  Considered an unlikely route of entry in commercial/industrial environments.  Accidental ingestion of the material may be damaging to the health of the individual.  Swallowing of the liquid may cause aspiration into the lungs with the risk of chemical pneumonitis; serious consequences may result. (ICSC13733).  Ingestion of petroleum hydrocarbons can irritate the pharynx, esophagus, stomach and small intestine, and cause swellings and ulcers of the mucous. Symptoms include a burning mouth and throat; larger amounts can cause nausea and vomiting, narcosis, weakness, dizziness, slow and shallow breathing, abdominal swelling, unconsciousness and convulsions. Damage to the heart muscle can produce heart beat irregularities, ventricular fibrillation (fatal) and ECG changes. The central nervous system can be depressed. Light species can cause a sharp tingling of the tongue and cause loss of sensation there. Aspiration can cause cough, gagging, pneumonia with swelling and bleeding.  Isoparaffinic hydrocarbons cause temporary lethargy, weakness,inco-ordination and diarrhea.  

EYE

  There is evidence that material may produce eye irritation in some persons and produce eye damage 24 hours or more after instillation. Severe inflammation may be expected with pain. There may be damage to the cornea. Unless treatment is prompt and adequate there may be permanent loss of vision. Conjunctivitis can occur following repeated exposure.  Direct eye contact with petroleum hydrocarbons can be painful, and the corneal epithelium may be temporarily damaged. Aromatic species can cause irritation and excessive tear secretion.  

SKIN

  Skin contact with the material may damage the health of the individual; systemic effects may result following absorption.  There is some evidence to suggest that the material may cause moderate inflammation of the skin either following direct contact or after a delay of some time. Repeated exposure can cause contact dermatitis which is characterized by redness, swelling and blistering.  Entry into the blood-stream, through, for example, cuts, abrasions or lesions, may produce systemic injury with harmful effects. Examine the skin prior to the use of the material and ensure that any external damage is suitably protected.  Absorption by skin may readily exceed vapor inhalation exposure. Symptoms for skin absorption are the same as for inhalation.  Excessive use or prolonged contact may lead to defatting, dryingand irritation of sensitive skin.  

INHALED

  Inhalation may produce health damage*.  Inhalation of vapors or aerosols (mists, fumes), generated by the material during the course of normal handling, may be damaging to the health of the individual.  There is some evidence to suggest that the material can cause respiratory irritation in some persons. The body's response to such irritation can cause further lung damage.  Inhalation of vapours may cause drowsiness and dizziness. This may be accompanied by narcosis, reduced alertness, loss of reflexes, lack of coordination and vertigo.  If exposure to highly concentrated solvent atmosphere is prolonged this may lead to narcosis, unconsciousness, even coma and possible death.  Acute effects from inhalation of high vapor concentrations may be chest and nasal irritation with coughing, sneezing, headache and even nausea.  Inhaling high concentrations of mixed hydrocarbons can cause narcosis, with nausea, vomiting and lightheadedness. Low molecular weight (C2-C12) hydrocarbons can irritate mucous membranes and cause incoordination, giddiness, nausea, vertigo, confusion, headache, appetite loss, drowsiness, tremors and stupor. Massive exposures can lead to severe central nervous system depression, deep coma and death. Convulsions can occur due to brain irritation and/or lack of oxygen. Permanent scarring may occur, with epileptic seizures and brain bleeds occurring months after exposure. Respiratory system effects include inflammation of the lungs with edema and bleeding. Lighter species mainly cause kidney and nerve damage; the heavier paraffins and olefins are especially irritant to the respiratory system. Alkenes produce pulmonary edema at high concentrations. Liquid paraffins may produce sensation loss and depressant actions leading to weakness, dizziness, slow and shallow respiration, unconsciousness, convulsions and death. C5-7 paraffins may also produce multiple nerve damage. Aromatic hydrocarbons accumulate in lipid rich tissues (typically the brain, spinal cord and peripheral nerves) and may produce functional impairment manifested by nonspecific symptoms such as nausea, weakness,  fatigue, vertigo; severe exposures may produce inebriation or unconsciousness. Many of the petroleum hydrocarbons can sensitize the heart and may cause ventricular fibrillation,  leading to death.  

CHRONIC HEALTH EFFECTS

  Skin contact with the material is more likely to cause a sensitization reaction in some persons compared to the general population.  

  There are generally two types of oximes: ketoximes derived from ketones and aldoximes derived form aldehydes. Several ketoximes (p-quinone dioxime, acetoxime and methyl ethyl ketoxime) have elicited carcinogenic effects on chronic exposure. Few substantive studies have been performed with aldoximes. The fact that aldoximes can be metabolised to cyanide via a pathway not applicable to ketoximes distinguishes the type of response which might be anticipated. Dehydration of aldoximes to produce nitriles has been shown to be catalysed in vitro by cytochrome P450; dehydration of ketoximes produces amides, rather than nitriles, via a Beckmann rearrangement but this apparently has no analogue in biological systems.  The mechanism and toxicity of oximes to erythrocytes is recognised and might be attributed to hydroxylamine, a product of hydrolysis. Hydroxylamine produces haematologic effects such as methaemoglobinaemia and splenomegaly in mice similar to those observed after exposure to oximes such as butanal oxime. Studies demonstrated the formation of haeme-associated free radicals in erythrocytes exposed to hydroxylamine, leading ultimately to peroxidation of membrane lipids. Lipid peroxidation in cellular membranes may produce several morphological alterations resulting, for example, in membrane aggregation, deformation or breakage. This may result in the release of hydrolytic enzymes which in turn may degrade functional macromolecules and cause secondary damage. In addition membrane-bound enzyme systems may be disrupted. Levels of hydroxylamine produced as a result of hydrolysis are thought to be too low to produce another sign of hydroxylamine toxicity, namely the formation of Heinz bodies  Oximes are not easily oxidised at near neutral conditions and hydrolysis by liver microsomes or S9 is hypothesised (however this conclusion was based on the formation of a ketone rather than hydroxylamine). Another possibility is that oximes are oxidatively metabolised to yield a ketone or aldehyde and some yet to be determined nitrogen-  containing species. Cytochrome P450 appears to provide a source of superoxide and hydrogen peroxide which catalyses oxidation in the presence of iron. At least part of the nitrogen in the oxime is converted to nitric oxide which complexes with haeme to give a nitrosylhaemoglobin complex.  There has been concern that this material can cause cancer or mutations, but there is not enough data to make an assessment.  Limited evidence suggests that repeated or long-term occupational exposure may produce cumulative health effects involving organs or biochemical systems.  Repeated application of mildly hydrotreated oils (principally paraffinic), to mouse skin, induced skin tumors; no tumors were induced with severely hydrotreated oils.  Constant or exposure over long periods to mixed hydrocarbons may produce stupor with dizziness, weakness and visual disturbance, weight loss and anemia, and reduced liver and kidney function. Skin exposure may result in drying and cracking and redness of the skin. Chronic exposure to lighter hydrocarbons can cause nerve damage, peripheral neuropathy, bone marrow dysfunction and psychiatric disorders as well as damage the liver and kidneys.  Oil may contact the skin or be inhaled. Extended exposure can lead to eczema, inflammation of hair follicles, pigmentation of the face and warts on the soles of the feet. Exposure to oil mists can cause asthma, pneumonia and scarring of the lungs. Oils have been linked to cancer of the skin and scrotum. Compounds that are less viscous and with smaller molecular weights are more dangerous. There may be liver damage and the lymph nodes may be affected; heart inflammation can also occur at high doses.