Section 1 - CHEMICAL PRODUCT AND COMPANY IDENTIFICATION

PRODUCT NAME

NANDROLONE DECANOATE

NFPA

PRODUCT USE

A hormone similar to testosterone but with anabolic effects more pronounced than its
androgenic properties. Given in conjunction with an adequate diet for conditions
characterised by protein loss and bone wasting. Used as adjunctive therapy for
osteoporosis. The decanoate is usually administered intramuscularly in oily solution.
Intermediate

SYNONYMS

C28-H44-O3, "estr-4-en-3-one, 17-beta-hydroxy-, decanoate", "estr-4-en-3-one, 17-beta-
hydroxy-, decanoate", "estr-4-en-3-one, 17-((1-oxodecyl)oxy)-, (17-beta)-", "estr-4-en-
3-one, 17-((1-oxodecyl)oxy)-, (17-beta)-", "17-beta-hydroxyestr-4-en-3-one decanoate",
"17-beta-hydroxyestr-4-en-3-one decanoate", "norandrostenalone decanoate", "19-
norandrostenalone decanoate", "19-norandrostenalone decanoate", "nor-testosterone
decanoate", "19-nortestosterone decanoate", "19-nortestosterone decanoate",
"nortestosterone decylate", "3-oxoestr-4-en-17-beta-yl decanoate", "3-oxoestr-4-en-17-
beta-yl decanoate", Deca-Durabol, Deca-Durabolin, Retabolil, "anabolic steroid androgen"

Section 2 - HAZARDS IDENTIFICATION

CANADIAN WHMIS SYMBOLS

EMERGENCY OVERVIEW

RISK

Very toxic to aquatic organisms, may cause long- term adverse effects in the
aquatic environment.

POTENTIAL HEALTH EFFECTS

ACUTE HEALTH EFFECTS

SWALLOWED

  Accidental ingestion of the material may be damaging to the health of the individual.  The anabolic steroids produce the adverse effects exhibited by androgens but generally produce lessened masculinizing effects, especially in women.  Androgens can cause increased bone mass, blood concentrations of nitrogen, sodium, potassium, calcium and phosphates, water retention and swelling, and blood vessel growth in the skin. They may cause premature closure of growth plates in early puberty causing reduced height. Obstructive jaundice and abnormal liver function may result. Allergic reactions which affect the skin ar also present. Large doses can permanently reduce the production of sperm in males. In women, androgens affect the pituitary gland and inhibit menstruation and the production of female sex hormones. Prolonged administration of large doses can cause masculinization with hair growth, deep voice, atrophy of breast and endometrial tissue, acne, blackheads, and an enlarged clitoris. Sexual desire is increased, but milk production is reduced.  

EYE

  Although the material is not thought to be an irritant, direct contact with the eye may cause transient discomfort characterized by tearing or conjunctival redness (as with windburn). Slight abrasive damage may also result. The material may produce foreign body irritation in certain individuals.  

SKIN

  The material is not thought to be a skin irritant (as classified using animal models). Abrasive damage however, may result from prolonged exposures. Good hygiene practice requires that exposure be kept to a minimum and that suitable gloves be used in an occupational setting.  Skin contact with the material may damage the health of the individual; systemic effects may result following absorption.  Entry into the blood-stream, through, for example, cuts, abrasions or lesions, may produce systemic injury with harmful effects. Examine the skin prior to the use of the material and ensure that any external damage is suitably protected.  

INHALED

  The material is not thought to produce either adverse health effects or irritation of the respiratory tract following inhalation (as classified using animal models). Nevertheless, adverse effects have been produced following exposure of animals by at least one other route and good hygiene practice requires that exposure be kept to a minimum and that suitable control measures be used in an occupational setting.  Persons with impaired respiratory function, airway diseases and conditions such as emphysema or chronic bronchitis, may incur further disability if excessive concentrations of particulate are inhaled.  

CHRONIC HEALTH EFFECTS

  There has been some concern that this material can cause cancer or mutations but there is not enough data to make an assessment.  There is some evidence that human exposure to the material may result in developmental toxicity. This evidence is based on animal studies where effects have been observed in the absence of marked maternal toxicity, or at around the same dose levels as other toxic effects but which are not secondary non-specific consequences of the other toxic effects.  Long term exposure to high dust concentrations may cause changes in lung function i.e. pneumoconiosis; caused by particles less than 0.5 micron penetrating and remaining in the lung. Prime symptom is breathlessness; lung shadows show on X-ray.  Exposure to the material for prolonged periods may cause physical defects in the developing embryo (teratogenesis).  High doses of androgens over prolonged periods may produce liver tumors and hasten growth of cancer of the prostate. In pregnant women, androgens may cause the development of male secondary sex characteristics of the female fetus.  Nandrolone may cause cholestatic jaundice, virilisation, oedema, congestive heart failure,  iron deficiency anaemia, hypercalcaemia, muscle cramps, gastrointestinal disturbances, retention of fluids, excitation, chills and toxic confusion. Chronic effects of exposure include peliosis hepatitis and blood lipid changes.