JOHNSONS ORTHOXICOL COLD & FLU CAPLETS
Flammability | 0 | |
Toxicity | 1 | |
Body Contact | 1 | |
Reactivity | 0 | |
Chronic | 2 | |
SCALE: Min/Nil=0 Low=1 Moderate=2 High=3 Extreme=4 |
Analgesic, antipyretic, cough suppressant and nasal decongestant. Used for temporary
relief of the following symptoms of cold and flu; headaches, body aches and pains, runny
nose, cough and fever. Recommended Dosage: Adults and children over 12 years: 2 caplets
four times daily. Not to be given to children under 12 years of age except on the advice
of a doctor. Hypertensive patients and those on antidepressant therapy should seek medical
advice before taking this preparation. This product should not be taken for chronic cough,
such as occurs with smoking, asthma or emphysema unless directed by a doctor.
Although ingestion is not thought to produce harmful effects, the material may still be damaging to the health of the individual following ingestion, especially where pre- existing organ (e.g. liver, kidney) damage is evident. Present definitions of harmful or toxic substances are generally based on doses producing mortality (death) rather than those producing morbidity (disease, ill-health). Gastrointestinal tract discomfort may produce nausea and vomiting. In an occupational setting however, ingestion of insignificant quantities is not thought to be cause for concern. Not considered an irritant through normal use.
Although the material is not thought to be an irritant, direct contact with the eye may produce transient discomfort characterized by tearing or conjunctival redness (as with windburn).
Skin contact with the material may damage the health of the individual; systemic effects may result following absorption. The material is not thought to be a skin irritant (as classified using animal models). Temporary discomfort, however, may result from prolonged dermal exposures. Good hygiene practice requires that exposure be kept to a minimum and that suitable gloves be used in an occupational setting.
The material is not thought to produce adverse health effects or irritation of the respiratory tract (as classified using animal models). Nevertheless, good hygiene practice requires that exposure be kept to a minimum and that suitable control measures be used in an occupational setting.
Principal route of exposure is usually by ingestion. The material may accumulate in the human body and progressively causetissue damage. A small fraction of an ingested dose may be metabolically activated in the liver and in the kidney to a form that reacts covalently with tissue nucleophiles. Toxic doses of the drug presumably deplete liver stores of reduced glutathione and the metabolite is then free to react with essential tissue macromolecules resulting in cell death and necrosis.