Section 1 - CHEMICAL PRODUCT AND COMPANY IDENTIFICATION

PRODUCT NAME

HAARMANN 456634 WHITE DRESS T60325RB

NFPA

PRODUCT USE

Fragrance compound.

SYNONYMS

"fragrance compound", perfume

Section 2 - HAZARDS IDENTIFICATION

CANADIAN WHMIS SYMBOLS

EMERGENCY OVERVIEW

RISK

Irritating to skin.
May cause SENSITIZATION by skin contact.
HARMFUL - May cause lung damage if swallowed.
Toxic to aquatic organisms, may cause long- term adverse effects in the aquatic
environment.

POTENTIAL HEALTH EFFECTS

ACUTE HEALTH EFFECTS

SWALLOWED

  Considered an unlikely route of entry in commercial/industrial environments.  Essential oils cause mild irritation of the mouth if taken orally, causing more saliva to be produced and a warm feeling. Large amounts affect the digestive system causing nausea, vomiting and diarrhea. Sometimes urination may be affected, causing difficulty or pain in urinating, reduced urine output, blood in the urine, unconsciousness and shallow breathing. Lung swelling and inflammation are possible complications. Stupor, excitement and respiratory failure may result, as well as convulsions; the central nervous system may either be depressed or stimulated. The kidneys may be damaged, and swelling and severe clogging can occur in the lungs, skin and kidneys. Essential oils increase the rate of miscarriage, but in low doses do not usually cause an abortion.  d-limonene, if ingested, causes a non-bloody diarrhea and abnormalities in bone formation. A strong urge to pass bowel may occur with little or no stools actually passed. In massive doses death may occur.  High oral doses of salicylates, such as aspirin, may cause a mild burning pain in the throat and stomach, causing vomiting. This is followed (within hours) by deep, rapid breathing, tiredness, nausea and further vomiting, thirst and diarrhea. The central nervous system is first stimulated, and then depression from failure occurs. Stimulation produces vomiting, hyperventilation, headache, ringing in the ears, confusion, behavior and mood changes, and generalized convulsions. Respiratory failure and cardiovascular collapse can result in death. There may also be sweating, skin eruptions, internal bleeding, kidney failure and inflamed pancreas. There may be bloody stools, purple skin spots or blood in the vomit. Many of these symptoms are due to disturbances in blood chemistry. A dose of 300 mg/kg can cause serious effects while 500 mg/kg can be lethal.  

EYE

  Although the liquid is not thought to be an irritant, direct contact with the eye may produce transient discomfort characterized by tearing or conjunctival redness (as with windburn).  

SKIN

  This material can cause inflammation of the skin oncontact in some persons.  The material may accentuate any pre-existing dermatitis condition.  Essential oils irritate the skin and redden it, causing at first warmth and smarting, followed by some local loss of sensation. They have been used to treat chronic inflammatory conditions and to relieve neuralgia and rheumatic pain. Care should be taken to avoid blistering; these oils may also produce sensitization.  d-limonene causes moderate irritation to skin including redness and swelling. Sometimes there are delayed hemorrhagic lesions.  

INHALED

  Inhalation may produce health damage*.  Not normally a hazard due to non-volatile nature of product.  The material is not thought to produce either adverse health effects or irritation of the respiratory tract following inhalation (as classified using animal models). Nevertheless, adverse effects have been produced following exposure of animals by at least one other route and good hygiene practice requires that exposure be kept to a minimum and that suitable control measures be used in an occupational setting.  

CHRONIC HEALTH EFFECTS

  Prolonged or continuous skin contact with the liquid may cause defatting with drying, cracking, irritation and dermatitis following.  Skin contact with the material is more likely to cause a sensitization reaction in some persons compared to the general population.  Intolerance to perfumes, by inhalation, may occur if the perfume contains a sensitising principal. Symptoms may vary from general illness, coughing, phlegm, wheezing, chest-  tightness, headache, exertional dyspnoea, acute respiratory illness, hayfever, and other respiratory diseases (including asthma). Perfumes can induce hyper-reactivity of the respiratory tract without producing an IgE-mediated allergy or demonstrable respiratory obstruction. This was shown by placebo-controlled challenges of nine patients to "perfume mix". The same patients were also subject to perfume provocation, with or without a carbon filter mask, to ascertain whether breathing through a filter with active carbon would prevent symptoms. The patients breathed through the mouth, during the provocations, as a nose clamp was used to prevent nasal inhalation. The patient's earlier symptoms were verified; breathing through the carbon filter had no protective effect. The symptoms were not transmitted via the olfactory nerve but they may have been induced by trigeminal reflex via the respiratory tract or by the eyes.  Cases of occupational asthma induced by perfume substances such as isoamyl acetate, limonene, cinnamaldehyde and benzaldehyde, tend to give persistent symptoms even though the exposure is below occupational exposure limits.  Inhalation intolerance has also been produced in animals. The emissions of five fragrance products, for one hour, produced various combinations of sensory irritation, pulmonary irritation, decreases in expiratory airflow velocity as well as alterations of the functional observational battery indicative of neurotoxicity in mice. Neurotoxicity was found to be more severe after mice were repeatedly exposed to the fragrance products, being four brands of cologne and one brand of toilet water.  Chronic exposure to salicylates produce problems with metabolism, central system disturbances, or kidney damage. Those with pre-existing damage to the eye, skin or kidney are especially at risk. Hypersensitive reactions can occur, especially in people with asthma. These symptoms include itchy wheals and other skin eruptions, an inflamed nose, shortness of breath and serious narrowing of the airways (which can even cause death). Chronic exposure to parabens by skin contact, ingestion or injection can cause hypersensitive reactions. There may be cross-sensitivity between different species, so people can be develop allergic symptoms if they were sensitized by other chemicals. Symptoms include acute narrowing of the airways, hives (itchy wheal), swelling, running nose and blurred vision. There may be anaphylactic shock and rash.