KNAB DUAL PURPOSE WASHOUT
Flammability | 2 | |
Toxicity | 2 | |
Body Contact | 2 | |
Reactivity | 1 | |
Chronic | 2 | |
SCALE: Min/Nil=0 Low=1 Moderate=2 High=3 Extreme=4 |
Wash out solution.
"printing industry"
HARMFUL - May cause lung damage if swallowed.
Irritating to eyes and skin.
Flammable.
Vapors may cause dizziness or suffocation.
Accidental ingestion of the material may be damaging to the health of the individual. Swallowing of the liquid may cause aspiration into the lungs with the risk of chemical pneumonitis; serious consequences may result. (ICSC13733). Polysaccharides are not substantially absorbed from the gastrointestinal tract but may produce a laxative effect. Larger doses may produce intestinal obstruction or stomach concretions.Large quantities of the substituted polysaccharide, methylcellulose (as with other bulk laxatives), may temporarily increase flatulence. Oesophageal obstruction, by swelling, may occur if the material is swallowed dry.Doses of 3-9 gm hydroxypropylcellulose, fed to human subjects, at least one week apart, were eliminated within 96 hours. Animals fed on diets containing 3% or less, experienced no adverse effects. Higher levels produced malnutrition due to excessive bulk but caused no organic damage. In one dog, an oral dose of hydroxypropylcellulose produced diarrhoea and blood cell depression.Ingestion of hetastarch (hydroxyethyl amylopectin) has reportedly produced fever, chills, urticaria and salivary gland enlargement. Several of these effects may be due to contamination by other naturally occurring macromolecules extracted from the source material. Large volumes of ingested hetastarch may interfere with coagulation mechanisms and increase the risk of haemorrhage. Anaphylaxis has occurred.Infusions of dextrans may occasionally produce allergic reactions such as urticaria,hypotension and bronchospasm. Severe anaphylactic reactions may occasionally occurand death may result from cardiac and respiratory arrest. Nausea, vomiting, fever, joint pains, and flushing may also occur. Similarly, allergic reactions, sometimes severe (but rare) have been reported following ingestion or inhalation of tragacanth gums. Ingestion of petroleum hydrocarbons can irritate the pharynx, esophagus, stomach and small intestine, and cause swellings and ulcers of the mucous. Symptoms include a burning mouth and throat; larger amounts can cause nausea and vomiting, narcosis, weakness, dizziness, slow and shallow breathing, abdominal swelling, unconsciousness and convulsions. Damage to the heart muscle can produce heart beat irregularities, ventricular fibrillation (fatal) and ECG changes. The central nervous system can be depressed. Light species can cause a sharp tingling of the tongue and cause loss of sensation there. Aspiration can cause cough, gagging, pneumonia with swelling and bleeding. Central nervous system (CNS) depression may include general discomfort, symptoms of giddiness, headache, dizziness, nausea, anaesthetic effects, slowed reaction time, slurred speech and may progress to unconsciousness. Serious poisonings may result in respiratory depression and may be fatal.
There is evidence that material may produce eye irritation in some persons and produce eye damage 24 hours or more after instillation. Severe inflammation may be expected with pain. There may be damage to the cornea. Unless treatment is prompt and adequate there may be permanent loss of vision. Conjunctivitis can occur following repeated exposure. Direct eye contact with petroleum hydrocarbons can be painful, and the corneal epithelium may be temporarily damaged. Aromatic species can cause irritation and excessive tear secretion.
This material can cause inflammation of the skin oncontact in some persons. The material may accentuate any pre-existing dermatitis condition. Entry into the blood-stream, through, for example, cuts, abrasions or lesions, may produce systemic injury with harmful effects. Examine the skin prior to the use of the material and ensure that any external damage is suitably protected. Aromatic hydrocarbons may produce sensitivity and redness of the skin. They are not likely to be absorbed into the body through the skin but branched species are more likely to.
Inhalation may produce health damage*. Inhalation of vapours may cause drowsiness and dizziness. This may be accompanied by narcosis, reduced alertness, loss of reflexes, lack of coordination and vertigo. Inhalation of high concentrations of gas/vapor causes lung irritation with coughing and nausea, central nervous depression with headache and dizziness, slowing of reflexes, fatigue and inco-ordination. If exposure to highly concentrated solvent atmosphere is prolonged this may lead to narcosis, unconsciousness, even coma and possible death. Exposure to white spirit, in a controlled inhalation study using volunteers either at rest or during exercise, (1000 or 2500 mg/m3 for 30 minutes) produced a linear relationship between alveolar and arterial concentrations of the individual solvent components. Pulmonary absorption of the aliphatics ranged from 46-59%, whilst that of aromatic ranged from 58-70%. Although systemic absorption was greater during exercise, the proportion of circulating aliphatic to aromatic components decreased with increased activity. Exposure to 2500 - 5000 mg/m3 produces nausea and vertigo.
There is some evidence that inhaling this product is more likely to cause a sensitization reaction in some persons compared to the general population.
Studies indicate that diets containing large amounts of non-absorbable polysaccharides, such as cellulose, might decrease absorption of calcium, magnesium, zinc and phosphorus. Limited evidence suggests that repeated or long-term occupational exposure may produce cumulative health effects involving organs or biochemical systems. Chronic solvent inhalation exposures may result in nervous system impairment and liver and blood changes. [PATTYS]. Constant or exposure over long periods to mixed hydrocarbons may produce stupor with dizziness, weakness and visual disturbance, weight loss and anemia, and reduced liver and kidney function. Skin exposure may result in drying and cracking and redness of the skin. Chronic exposure to lighter hydrocarbons can cause nerve damage, peripheral neuropathy, bone marrow dysfunction and psychiatric disorders as well as damage the liver and kidneys. Follicular dermatitis may develop rapidly on repeated immersion of the hands and forearms in white spirits. A Belgian report, produced in 1958, described sub-chronic toxicity amongst workers exposed to white spirit (83% paraffins, 17% aromatics) over a 4 month period. These workers complained of nausea and vomiting and one developed aplastic anaemia; bone marrow depression was confirmed. This employee died several months later as a result of septicaemia. Bone marrow depression, associated with human exposure, might be explained by the presence of myelotoxic compounds, the most notable being benzene.