KURETAKE ZIG OPAQUE PEN OP-330/220/100/88/55/120 (INK)
Flammability | 1 | |
Toxicity | 2 | |
Body Contact | 2 | |
Reactivity | 2 | |
Chronic | 3 | |
SCALE: Min/Nil=0 Low=1 Moderate=2 High=3 Extreme=4 |
Used according to manufacturer' s directions.
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In use, may form flammable/ explosive vapor- air mixture.
May form explosive peroxides.
May impair fertility.
May cause harm to the unborn child.
HARMFUL - May cause lung damage if swallowed.
Harmful by inhalation, in contact with skin and if swallowed.
Irritating to eyes and respiratory system.
Repeated exposure may cause skin dryness and cracking.
Accidental ingestion of the material may be harmful; animal experiments indicate that ingestion of less than 150 gram may be fatal or may produce serious damage to the health of the individual. There is some evidence to suggest that this material can cause, if swallowed once, irreversible damage of organs. Central nervous system (CNS) depression may include general discomfort, symptoms of giddiness, headache, dizziness, nausea, anaesthetic effects, slowed reaction time, slurred speech and may progress to unconsciousness. Serious poisonings may result in respiratory depression and may be fatal. Overexposure to non-ring alcohols causes nervous system symptoms. These include headache, muscle weakness and inco-ordination, giddiness, confusion, delirium and coma. Digestive symptoms may include nausea, vomiting and diarrhea. Aspiration is much more dangerous than ingestion because lung damage can occur and the substance is absorbed into the body. Alcohols with ring structures and secondary and tertiary alcohols cause more severe symptoms, as do heavier alcohols.
There is evidence that material may produce eye irritation in some persons and produce eye damage 24 hours or more after instillation. Severe inflammation may be expected with pain. There may be damage to the cornea. Unless treatment is prompt and adequate there may be permanent loss of vision. Conjunctivitis can occur following repeated exposure. The liquid may produce eye discomfort and is capable of causing temporary impairment of vision and/or transient eye inflammation, ulceration. The material may produce severe irritation to the eye causing pronounced inflammation. Repeated or prolonged exposure to irritants may produce conjunctivitis.
Skin contact with the material may be harmful; systemic effects may resultfollowing absorption. There is some evidence to suggest that this material, on a single contact with skin, can cause irreversible damage of organs. There is some evidence to suggest that the material may cause mild but significant inflammation of the skin either following direct contact or after a delay of some time. Repeated exposure can cause contact dermatitis which is characterized by redness, swelling and blistering. Repeated exposure may cause skin cracking, flaking or drying following normal handling and use. Entry into the blood-stream, through, for example, cuts, abrasions or lesions, may produce systemic injury with harmful effects. Examine the skin prior to the use of the material and ensure that any external damage is suitably protected. Toxic effects may result from skin absorption. Exposure limits with "skin" notation indicate that vapor and liquid may be absorbed through intact skin. Absorption by skin may readily exceed vapor inhalation exposure. Symptoms for skin absorption are the same as for inhalation. Contact with eyes and mucous membranes may also contribute to overall exposure and may also invalidate the exposure standard. The material may cause skin irritation after prolonged or repeated exposure and may produce on contact skin redness, swelling, the production of vesicles, scaling and thickening of the skin.
There is some evidence to suggest that this material can cause, if inhaled once, irreversible damage of organs. The material can cause respiratory irritation in some persons. The body's response to such irritation can cause further lung damage. Ketone vapors irritate the nose, throat and mucous membrane. High concentrations depress the central nervous system, causing headache, vertigo, poor concentration, sleep and failure of the heart and breathing. Some ketones can cause multiple nerve disorders, inducing "pins and needles" and weakness in the limbs. If exposure to highly concentrated solvent atmosphere is prolonged this may lead to narcosis, unconsciousness, even coma and possible death.
Ample evidence exists from experimentation that reduced human fertility is directly caused by exposure to the material. Ample evidence exists, from results in experimentation, that developmental disorders are directly caused by human exposure to the material.
Limited evidence suggests that repeated or long-term occupational exposure may produce cumulative health effects involving organs or biochemical systems. Asthma-like symptoms may continue for months or even years after exposure to the material ceases. This may be due to a non-allergenic condition known as reactive airways dysfunction syndrome (RADS) which can occur following exposure to high levels of highly irritating compound. Key criteria for the diagnosis of RADS include the absence of preceding respiratory disease, in a non-atopic individual, with abrupt onset of persistent asthma-like symptoms within minutes to hours of a documented exposure to the irritant. A reversible airflow pattern, on spirometry, with the presence of moderate to severe bronchial hyperreactivity on methacholine challenge testing and the lack of minimal lymphocytic inflammation, without eosinophilia, have also been included in the criteria for diagnosis of RADS. RADS (or asthma) following an irritating inhalation is an infrequent disorder with rates related to the concentration of and duration of exposure to the irritating substance. Industrial bronchitis, on the other hand, is a disorder that occurs as result of exposure due to high concentrations of irritating substance (often particulate in nature) and is completely reversible after exposure ceases. The disorder is characterised by dyspnea, cough and mucus production. There has been some concern that this material can cause cancer or mutations but there is not enough data to make an assessment. Exposure to the material for prolonged periods may cause physical defects in the developing embryo (teratogenesis). Ethylene glycol esters and their ethers cause wasting of the testicles, reproductive changes, infertility and changes to kidney function. Shorter chain compounds are more dangerous. They are also associated with the formation of stones in the urine. Chronic solvent inhalation exposures may result in nervous system impairment and liver and blood changes. [PATTYS].