Section 1 - CHEMICAL PRODUCT AND COMPANY IDENTIFICATION

PRODUCT NAME

HAARMANN 717596 CITRODOR 23275

NFPA

PRODUCT USE

Frangrance compound.

SYNONYMS

"fragrance compound"

Section 2 - HAZARDS IDENTIFICATION

CANADIAN WHMIS SYMBOLS

EMERGENCY OVERVIEW

RISK

Irritating to skin.
May cause SENSITIZATION by skin contact.
HARMFUL - May cause lung damage if swallowed.
Harmful by inhalation, in contact with skin and if swallowed.
Harmful to aquatic organisms, may cause long- term adverse effects in the
aquatic environment.

POTENTIAL HEALTH EFFECTS

ACUTE HEALTH EFFECTS

SWALLOWED

  Accidental ingestion of the material may be damaging to the health of the individual.  Essential oils cause mild irritation of the mouth if taken orally, causing more saliva to be produced and a warm feeling. Large amounts affect the digestive system causing nausea, vomiting and diarrhea. Sometimes urination may be affected, causing difficulty or pain in urinating, reduced urine output, blood in the urine, unconsciousness and shallow breathing. Lung swelling and inflammation are possible complications. Stupor, excitement and respiratory failure may result, as well as convulsions; the central nervous system may either be depressed or stimulated. The kidneys may be damaged, and swelling and severe clogging can occur in the lungs, skin and kidneys. Essential oils increase the rate of miscarriage, but in low doses do not usually cause an abortion.  An estimated acceptable daily intake of up to 500 microgram per kilogram body weight was estimated for the terpene/ terpenoids, citral, geranyl acetate, citronellol, linalool and linaly acetate (expressed as citral).  Twenty-third Report of the Joint FAO/WHO Expert Committee on Food Additives  Tech. Rep. Ser. Wld Hlth Org. No. 648, 1980.  High oral doses of salicylates, such as aspirin, may cause a mild burning pain in the throat and stomach, causing vomiting. This is followed (within hours) by deep, rapid breathing, tiredness, nausea and further vomiting, thirst and diarrhea. The central nervous system is first stimulated, and then depression from failure occurs. Stimulation produces vomiting, hyperventilation, headache, ringing in the ears, confusion, behavior and mood changes, and generalized convulsions. Respiratory failure and cardiovascular collapse can result in death. There may also be sweating, skin eruptions, internal bleeding, kidney failure and inflamed pancreas. There may be bloody stools, purple skin spots or blood in the vomit. Many of these symptoms are due to disturbances in blood chemistry. A dose of 300 mg/kg can cause serious effects while 500 mg/kg can be lethal.  

EYE

  This material can cause eye irritation and damage in some persons.  Precautions for handling reactive unsaturated aldehydes should be the same as for those of highly active eye and pulmonary irritants such as phosgene. Sufficient engineering controls, with monitoring where possible, are of importance.  

SKIN

  Skin contact with the material may be harmful; systemic effects may resultfollowing absorption.  This material can cause inflammation of the skin oncontact in some persons.  The material may accentuate any pre-existing dermatitis condition.  Skin contact is not thought to have harmful health effects, however the material may still produce health damage following entry through wounds, lesions or abrasions.  Entry into the blood-stream, through, for example, cuts, abrasions or lesions, may produce systemic injury with harmful effects. Examine the skin prior to the use of the material and ensure that any external damage is suitably protected.  Essential oils irritate the skin and redden it, causing at first warmth and smarting, followed by some local loss of sensation. They have been used to treat chronic inflammatory conditions and to relieve neuralgia and rheumatic pain. Care should be taken to avoid blistering; these oils may also produce sensitization.  Irritating to skin.  The material may cause severe skin irritation after prolonged or repeated exposure and may produce on contact skin redness, swelling, the production of vesicles, scaling and thickening of the skin. Repeated exposures may produce severe ulceration.  

INHALED

  Inhalation of vapors or aerosols (mists, fumes), generated by the material during the course of normal handling, may be damaging to the health of the individual.  The material can cause respiratory irritation in some persons. The body's response to such irritation can cause further lung damage.  Inhalation of vapours may cause drowsiness and dizziness. This may be accompanied by narcosis, reduced alertness, loss of reflexes, lack of coordination and vertigo.  Inhalation of quantities of liquid mist may be extremely hazardous, even lethal due to spasm, extreme irritation of larynx and bronchi, chemical pneumonitis and pulmonary edema.  Inhalation of essential oil volatiles may cause dizziness, rapid, shallow breathing, increased heart rate, respiratory irritation, loss of consciousness or convulsions. Urination may stop, and there may be swelling and inflammation of the lungs.  Exposure to aldehydes causes neurological symptoms such as headache, drowsiness, dizziness, seizures, depression and coma. Cardiovascular involvement may result in increased heart rate, collapse and low blood pressure; respiratory effects include throat spasms, irritation, difficulty swallowing, pulmonary edema and an asthma-like condition. Gastrointestinal signs include nausea, blood in vomit, diarrhea, ulcers and abdominal pain. Massive exposures may damage the kidney and liver.  

CHRONIC HEALTH EFFECTS

  Limited evidence suggests that repeated or long-term occupational exposure may produce cumulative health effects involving organs or biochemical systems.  Asthma-like symptoms may continue for months or even years after exposure to the material ceases. This may be due to a non-allergenic condition known as reactive airways dysfunction syndrome (RADS) which can occur following exposure to high levels of highly irritating compound. Key criteria for the diagnosis of RADS include the absence of preceding respiratory disease, in a non-atopic individual, with abrupt onset of persistent asthma-like symptoms within minutes to hours of a documented exposure to the irritant. A reversible airflow pattern, on spirometry, with the presence of moderate to severe bronchial hyperreactivity on methacholine challenge testing and the lack of minimal lymphocytic inflammation, without eosinophilia, have also been included in the criteria for diagnosis of RADS. RADS (or asthma) following an irritating inhalation is an infrequent disorder with rates related to the concentration of and duration of exposure to the irritating substance. Industrial bronchitis, on the other hand, is a disorder that occurs as result of exposure due to high concentrations of irritating substance (often particulate in nature) and is completely reversible after exposure ceases. The disorder is characterised by dyspnea, cough and mucus production.  Skin contact with the material is more likely to cause a sensitization reaction in some persons compared to the general population.  Chronic exposure to salicylates produce problems with metabolism, central system disturbances, or kidney damage. Those with pre-existing damage to the eye, skin or kidney are especially at risk. Hypersensitive reactions can occur, especially in people with asthma. These symptoms include itchy wheals and other skin eruptions, an inflamed nose, shortness of breath and serious narrowing of the airways (which can even cause death). Chronic exposure to parabens by skin contact, ingestion or injection can cause hypersensitive reactions. There may be cross-sensitivity between different species, so people can be develop allergic symptoms if they were sensitized by other chemicals. Symptoms include acute narrowing of the airways, hives (itchy wheal), swelling, running nose and blurred vision. There may be anaphylactic shock and rash.  May cause SENSITIZATION by skin contact.  Contact allergies quickly manifest themselves as contact eczema, more rarely as urticaria or Quincke's edema. The pathogenesis of contact eczema involves a cell-mediated (T lymphocytes) immune reaction of the delayed type. Other allergic skin reactions, e.g. contact urticaria, involve antibody-mediated immune reactions. The significance of the contact allergen is not simply determined by its sensitization potential: the distribution of the substance and the opportunities for contact with it are equally important. A weakly sensitizing substance which is widely distributed can be a more important allergen than one with stronger sensitizing potential with which few individuals come into contact. From a clinical point of view, substances are noteworthy if they produce an allergic test reaction in more than 1% of the persons tested.