Section 1 - CHEMICAL PRODUCT AND COMPANY IDENTIFICATION

PRODUCT NAME

JASMOLIN II

NFPA

PRODUCT USE

Extracted from pyrethrum flowers, the active component is used in space spray formulations
to knock down household insects such as flies, mosquitoes, garden insects. Also has some
repellent properties. Pyrethrins as stabilized extracts are generally formulated in oil or
hydrocarbon solvents of kerosene type. Typical pyrethrin contents may be 0.05- 1.0%; and
synergists are used. Pyrethrins can also be found in powder form.

SYNONYMS

C22-H30-O5, "3-(3-methoxy-2-methyl-3-oxo-1-propenyl)-2, 2-
dimethylcyclopropanecarboxylicacid 2-methyl-4-oxo-3-(2-penteneyl)-2-cyclopenten-1-yl
ester", "3-(3-methoxy-2-methyl-3-oxo-1-propenyl)-2, 2-dimethylcyclopropanecarboxylicacid
2-methyl-4-oxo-3-(2-penteneyl)-2-cyclopenten-1-yl ester", "4', 5'-dihydropyrethrin II",
"4', 5'-dihydropyrethrin II", "4', 5'-dihydropyrethrin II", "4', 5'-dihydropyrethrin II",
"pyrethrum constituent (pyrethrin)"

Section 2 - HAZARDS IDENTIFICATION

CANADIAN WHMIS SYMBOLS

EMERGENCY OVERVIEW

RISK

Harmful by inhalation, in contact with skin and if swallowed.

POTENTIAL HEALTH EFFECTS

ACUTE HEALTH EFFECTS

SWALLOWED

  Accidental ingestion of the material may be harmful; animal experiments indicate that ingestion of less than 150 gram may be fatal or may produce serious damage to the health of the individual.  Ingestion of pyrethrins may produce nausea, vomiting, headache and other central nervous system disturbances. Excitation, muscular tremors and a period of shock may be followed by death. Dogs fed 5000 ppm of pyrethrum, for 90 days, developed dyspnae, tremors, ataxia and excessive salivation. An estimated fatal human dose is thought to be 100 gms. for a typical 70 kg man (1430 mg/kg).  

EYE

  Although the material is not thought to be an irritant, direct contact with the eye may produce transient discomfort characterized by tearing or conjunctival redness (as with windburn).  

SKIN

  Skin contact with the material may be harmful; systemic effects may resultfollowing absorption.  The material is not thought to be a skin irritant (as classified using animal models). Temporary discomfort, however, may result from prolonged dermal exposures. Good hygiene practice requires that exposure be kept to a minimum and that suitable gloves be used in an occupational setting.  Toxic effects may result from skin absorption.  Skin contact with natural pyrethrins may result in severe dermatitis and may also be associated with allergic rhinitis and asthma. Absorption through the skin may result in a toxic syndrome similar to that produced by inhalation. Systemic effects, following skin absorption, may include liver and kidney damage. Prolonged or repeated exposure may cause central nervous system effects and allergic skin reaction.  

INHALED

  The material is not thought to produce respiratory irritation (as classified using animal models). Nevertheless inhalation of the material, especially for prolonged periods, may produce respiratory discomfort and occasionally, distress.  Inhalation of vapor may aggravate a pre-existing respiratory condition.  Inhalation of pyrethrins may produce nausea, vomiting, sneezing, serious nasal discharge, nasal stuffiness and asthma. High concentrations may produce hyperexcitability, incoordination, tremors, muscular paralysis and death (due to respiratory failure).  There have been some reports of transient facial tingling (paraesthesia) which lasts a few hours after exposure.  

CHRONIC HEALTH EFFECTS

  There is some evidence that inhaling this product is more likely to cause a sensitization reaction in some persons compared to the general population.  

  Principal routes of exposure are by accidental skin and eye contact and by inhalation of vapors especially at higher temperatures.  Chronic poisoning by natural pyrethrins may result in convulsion, tetanic paralysis, rapid and uneven heart beat, liver and kidney damage, or death.  The natural pyrethrins may produce hypersensitivity, especially following previous sensitising exposure. In general, repeated exposures over 2 or 3 years are required to elicit a response and involve exposure to pyrethrum rather than its individual components (including pyrethrins). The sesquiterpene lactone (pyrethrosin) and the pyrethrum glycoproteins account for the immediate and delayed hypersensitivity seen in guinea pigs following a single injection of ground chrysanthemum in Freud's adjuvant. Mild erythematic vesicular dermatitis (with papules), pruritus, localized oedema (particularly of the face, lips and eyelids), rhinitis, tachycardia, pallor and sweating are the most common syndromes. An initial skin sensitisation can progress to marked dermal oedema and skin cracking. Pyrethrum dermatitis appears to increase in hot weather or under conditions were heavy perspiration is produced. The active ingredients of pyrethrum (except pyrethrin II) are inactive in patch tests. Those patients allergic to ragweed pollen are particularly sensitive to pyrethrin.  Rats fed on a diet of pyrethrins for 5000 ppm for 2 years showed some signs of tissue damage including liver lesions, bile duct proliferation and focal necrosis of the liver cells. A no-effect level of 1000 ppm found in animal experiments correspond to a daily dose of 3600 mg/man.