WESSEX POLYMERS COSMONATE 200
Flammability | 1 | |
Toxicity | 2 | |
Body Contact | 2 | |
Reactivity | 2 | |
Chronic | 2 | |
SCALE: Min/Nil=0 Low=1 Moderate=2 High=3 Extreme=4 |
A component of polyurethane resins, foams, mastics, coatings. Requires that the two parts
be mixed by hand or mixer before use, in accordance with manufacturers directions. Mix
only as much as is required. Do not return the mixed material to the original containers.
CONTAINS free organic isocyanate. Mixing and application requires special precautions and
use of personal protective gear [APMF].
C15-H10-N2-O2, CH2(C6-H4-N-CO)2, CH2(C6-H4-N-CO)2, "isocyanic acid, methylenedi-p-
phenylene ester", "isocyanic acid, methylenedi-p-phenylene ester", MDI, "diphenyl
methane diisocyanate", "diphenylmethane diisocyanate", "methylene diisocyanate", "benzene,
1, 1'-methylenebis(4-isocyanato)", "methylene bis(p-phenyl isocyanate)", "methylenebis(4-
phenyl isocyanate)", "p, p'-diphenylmethane diisocyanate", "p, p'-diphenylmethane
diisocyanate", "methylenebisphenyl isocyanate", di(4-iso-cyanatophenyl)-methane,
"methylenedi-p-phenylene diisocyanate", "methylenedi-p-phenylene diisocyanate",
"methylene bisphenol isocyanate", methylenebis(4-isocyanatobenzene)
Harmful by inhalation.
May cause SENSITIZATION by inhalation and skin contact.
Irritating to eyes, respiratory system and skin.
Although ingestion is not thought to produce harmful effects, the material may still be damaging to the health of the individual following ingestion, especially where pre- existing organ (e.g. liver, kidney) damage is evident. Present definitions of harmful or toxic substances are generally based on doses producing mortality (death) rather than those producing morbidity (disease, ill-health). Gastrointestinal tract discomfort may produce nausea and vomiting. In an occupational setting however, ingestion of insignificant quantities is not thought to be cause for concern. Considered an unlikely route of entry in commercial/industrial environments. Ingestion may result in nausea, abdominal irritation, pain and vomiting.
This material can cause eye irritation and damage in some persons. The material may produce moderate eye irritation leading to inflammation. Repeated or prolonged exposure to irritants may produce conjunctivitis.
This material can cause inflammation of the skin oncontact in some persons. Skin contact is not thought to have harmful health effects, however the material may still produce health damage following entry through wounds, lesions or abrasions. Sensitization may result in allergic dermatitis responses includingrash, itching, hives or swelling of extremities. Bare unprotected skin should not be exposed to this material. Toxic effects may result from skin absorption. Contact allergies quickly manifest themselves as contact eczema, more rarely as urticaria or Quincke's edema. The pathogenesis of contact eczema involves a cell-mediated (T lymphocytes) immune reaction of the delayed type. Other allergic skin reactions, e.g. contact urticaria, involve antibody-mediated immune reactions. The significance of the contact allergen is not simply determined by its sensitization potential: the distribution of the substance and the opportunities for contact with it are equally important. A weakly sensitizing substance which is widely distributed can be a more important allergen than one with stronger sensitizing potential with which few individuals come into contact. From a clinical point of view, substances are noteworthy if they produce an allergic test reaction in more than 1% of the persons tested.
If inhaled, this material can irritate the throat andlungs of some persons. The vapor/mist may be highly irritating to the upper respiratory tract and lungs; the response may be severe enough to produce bronchitis and pulmonary edema. Possible neurological symptoms arising from isocyanate exposure include headache, insomnia, euphoria, ataxia, anxiety neurosis, depression and paranoia. Gastrointestinal disturbances are characterized by nausea and vomiting. Pulmonary sensitization may produce asthmatic reactions ranging from minor breathing difficulties to severe allergic attacks; this may occur following a single acute exposure or may develop without warning for several hours after exposure. Sensitized people can react to very low doses, and should not be allowed to work in situations allowing exposure to this material. Continued exposure of sensitized persons may lead to possible long term respiratory impairment.Inhalation hazard is increased at higher temperatures. Inhalation of vapor may aggravate a pre-existing respiratory condition. Allergic reactions involving the respiratory tract are usually due to interactions between IgE antibodies and allergens and occur rapidly. Allergic potential of the allergen and period of exposure often determine the severity of symptoms. Some people may be genetically more prone than others, and exposure to other irritants may aggravate symptoms. Allergy causing activity is due to interactions with proteins. Attention should be paid to atopic diathesis, characterized by increased susceptibility to nasal inflammation, asthma and eczema.
Inhaling this product is more likely to cause a sensitization reaction in some persons compared to the general population. Skin contact with the material is more likely to cause a sensitization reaction in some persons compared to the general population.
Principal routes of exposure are usually by inhalation of vapor and skin contact/absorption. Isocyanate vapors are irritating to the airways and can cause their inflammation, with wheezing, gasping, severe distress, even loss of consciousness and fluid in the lungs. Nervous system symptoms that may occur include headache, sleep disturbance, euphoria, inco-ordination, anxiety, depression and paranoia. Digestive effects include nausea and vomiting. Breathing difficulties may occur unpredictably after a period of tolerance and after skin contact. Allergic inflammation of the skin can occur, with rash, itching, blistering, and swelling of the hands and feet. Sensitive people can react to very low levels and should not be exposed to this material. Respiratory sensitization may result in allergic/asthma like responses; from coughing and minor breathing difficulties to bronchitis with wheezing, gasping. Sensitization may give severe responses to very low levels of exposure, i.e. hypersensitivity. Sensitized persons should not be allowed to work in situations where exposure may occur.