Section 1 - CHEMICAL PRODUCT AND COMPANY IDENTIFICATION

PRODUCT NAME

RESCINNAMINE

NFPA

PRODUCT USE

An alkaloid obtained from the roots of species of Rauwolfia (Apocynaceae), Rauwolfia
serpentina and R. vomitoria, or by synthesis. A sedative and central nervous depressant.
Causes depletion of the noradrenaline stores in the peripheral sympathetic nerve terminals
and depletion of catecholamine and serotonin stores in the brain, heart and many other
organs. Normally given by mouth where its action is slow in onset and continues for some
days after withdrawal of treatment. It has a cumulative effect; tolerance does not
develop. Used in the treatment of hypertension and as a sedative in anxiety states and
chronic psychoses.

SYNONYMS

C35-H42-N2-O9, "3-beta, 20-alpha-yohimban-16-beta-carboxylic acid, ", "3-beta, 20-alpha-
yohimban-16-beta-carboxylic acid, ", "18-beta-hydroxy-11, 17-alpha-dimethoxy-, methyl
ester, ", "18-beta-hydroxy-11, 17-alpha-dimethoxy-, methyl ester, ", "3, 4, 5-
trimethoxycinnamate (ester)", "3, 4, 5-trimethoxycinnamate (ester)", "11, 17-demethoxy-18-
[[1-oxo-3-3, 4, 5-trimethoxyphenyl)-2-propenyl]oxy]-3, 20-", "11, 17-demethoxy-18-[[1-oxo-
3-3, 4, 5-trimethoxyphenyl)-2-propenyl]oxy]-3, 20-", "yohimban-16-carboxylic acid methyl
ester", "yohimban-16-carboxylic acid methyl ester", "methyl 18-O-(3, 4, 5-
trimethoxycinnamoyl)reserpate", "methyl 18-O-(3, 4, 5-trimethoxycinnamoyl)reserpate",
"methyl reserpate 3, 4, 5-trimethoxycinnamic acid ester", "methyl reserpate 3, 4, 5-
trimethoxycinnamic acid ester", reserpinene, reserpinin, reserpinine,
"trimethoxycinnamoyl methyl reserpate", "3, 4, 5-trimethylcinnamoyl methyl reserpate", "3,
4, 5-trimethylcinnamoyl methyl reserpate", Anapral, Anaprel, Cinamine, Cinatabs, Moderil,
Normorescina, Raupyrol, Raurescine, Rescinpal, Rescisan, Rescitens, Resipal, Tuareg,
Reskinnamin, Scinnamina, Tenamine, "reserpine analogue", "tranquilliser/ tranquillizer",
antihypertensive, sedative

Section 2 - HAZARDS IDENTIFICATION

CANADIAN WHMIS SYMBOLS

EMERGENCY OVERVIEW

RISK

Harmful if swallowed.

POTENTIAL HEALTH EFFECTS

ACUTE HEALTH EFFECTS

SWALLOWED

  Accidental ingestion of the material may be harmful; animal experiments indicate that ingestion of less than 150 gram may be fatal or may produce serious damage to the health of the individual.  

EYE

  Although the material is not thought to be an irritant, direct contact with the eye may produce transient discomfort characterized by tearing or conjunctival redness (as with windburn).  The dust may produce eye discomfort causing smarting, pain and redness.  

SKIN

  The material is not thought to produce adverse health effects or skin irritation following contact (as classified using animal models). Nevertheless, good hygiene practice requires that exposure be kept to a minimum and that suitable gloves be used in an occupational setting.  Toxic effects may result from skin absorption.  

INHALED

  Inhalation may produce health damage*.  The material is not thought to produce respiratory irritation (as classified using animal models). Nevertheless inhalation of the material, especially for prolonged periods, may produce respiratory discomfort and occasionally, distress.  Persons with impaired respiratory function, airway diseases and conditions such as emphysema or chronic bronchitis, may incur further disability if excessive concentrations of particulate are inhaled.  

CHRONIC HEALTH EFFECTS

  Principal routes of exposure are by ingestion and accidental skin contact  or inhalation of dusts.  No human exposure data available. For this reason health effects described are based on experience with chemically related materials.  As with any chemical product, contact with unprotected bare skin; inhalation of vapor, mist or dust in work place atmosphere; or ingestion in any form, should be avoided by observing good occupational work practice.