VINYLPYRROLIDONE HOMOPOLYMER
Flammability | 1 | |
Toxicity | 0 | |
Body Contact | 0 | |
Reactivity | 1 | |
Chronic | 2 | |
SCALE: Min/Nil=0 Low=1 Moderate=2 High=3 Extreme=4 |
Blood plasma extender; in pharmacy for tabletting; detoxification of chemicals and drugs;
in laundry detergents to prevent dye transfer, cosmetics, hair setting compositions,
textile finishes, protective colloids, detergents, adhesives, beer & wine clarification.
NOTE: Polyvinylpolypyrrolidone [CAS RN: 25249- 54- 1] is the highly cross- linked form of
polyvinylpyrrolidone.
(C6H9NO)n, poly(vinylpyrrolidone), "polyvinyl pyrrolidone", polyvinylpyrrolidone, PVP,
PVPP, Povidone, "Luviskol K17 K25 K30 K60 K80 K90 KPO", "1-ethenyl-2-pyrrolidinone
polymer", "1-ethenyl-2-pyrrolidinone polymer", "1-ethenyl-2-pyrrolidinone homopolymer",
"1-ethenyl-2-pyrrolidinone homopolymer", "2-pyrrolidinone, 1-ethenyl polymer", "2-
pyrrolidinone, 1-ethenyl polymer", "2-pyrrolidinone, 1-ethenyl homopolymer", "2-
pyrrolidinone, 1-ethenyl homopolymer", Hemodesis, Hemodez, Kollidon, Peragal, Periston,
Peviston, Plasdone, Polyclar, "vinylpyrrolidone polymer", "vinylpyrolidone homopolymer
(sic)", "polyvinylpyrolidone (sic)", "polyvinyl pyrolidone (sic)", "Huepners Polymer 1,
2, 3, 4, 5, 6, 7", Crospovidone, PVP-25, PVP-40, PVP-50, PVP-1230, "Disentex 75"
None
High molecular weight material; on single acute exposure would be expected to pass through gastrointestinal tract with little change / absorption. Occasionally accumulation of the solid material within the alimentary tract may result in formation of a bezoar (concretion), producing discomfort. Although ingestion is not thought to produce harmful effects, the material may still be damaging to the health of the individual following ingestion, especially where pre- existing organ (e.g. liver, kidney) damage is evident. Present definitions of harmful or toxic substances are generally based on doses producing mortality (death) rather than those producing morbidity (disease, ill-health). Gastrointestinal tract discomfort may produce nausea and vomiting. In an occupational setting however, ingestion of insignificant quantities is not thought to be cause for concern.
Although the material is not thought to be an irritant, direct contact with the eye may cause transient discomfort characterized by tearing or conjunctival redness (as with windburn). Slight abrasive damage may also result. The material may produce foreign body irritation in certain individuals.
Entry into the blood-stream, through, for example, cuts, abrasions or lesions, may produce systemic injury with harmful effects. Examine the skin prior to the use of the material and ensure that any external damage is suitably protected. The material is not thought to produce adverse health effects or skin irritation following contact (as classified using animal models). Nevertheless, good hygiene practice requires that exposure be kept to a minimum and that suitable gloves be used in an occupational setting.
The material is not thought to produce adverse health effects or irritation of the respiratory tract (as classified using animal models). Nevertheless, good hygiene practice requires that exposure be kept to a minimum and that suitable control measures be used in an occupational setting.
This material contains a substantial amount of polymer considered to be of low concern. These are classified under having MWs of between 1000 to 10000 with less than 25% of molecules with MWS under 1000 and less than 10% under 500; or having a molecular weight average of over 10000. Functional groups contained on the polymer are then classified into risk categories. Being classified as a polymer of "low concern" does not mean that there are no hazards associated with the chemical. Long term exposure to high dust concentrations may cause changes in lung function i.e. pneumoconiosis; caused by particles less than 0.5 micron penetrating and remaining in the lung. Prime symptom is breathlessness; lung shadows show on X-ray. There has been some concern that this material can cause cancer or mutations but there is not enough data to make an assessment. PVP is non-antigenic and generally well tolerated. PVP has been shown to cause sarcomas in rats but there is not confirmation that it is carcinogenic in human patients. [Martindale] The material may cause irritation or dermatitis in some individuals upon prolonged contact.