LEVAMISOLE HYDROCHLORIDE
Flammability | 1 | |
Toxicity | 3 | |
Body Contact | 0 | |
Reactivity | 1 | |
Chronic | 2 | |
SCALE: Min/Nil=0 Low=1 Moderate=2 High=3 Extreme=4 |
Veterinary use as worming oral drench for sheep and cattle (anthelmintic). In medicine for
treatment of roundworm, hookworm and strongyloids. As an immunomodulator, it restores
certain functions of T lymphocytes and phagocytes. In experimental medicine for treatment
of arthritis, brucellosis, Crohn' s disease, filaria, herpes, hepatitis, tropical
eosinophilia, tuberculosis.
C11-H12-N2-S.HCl, "imidazo(2, 1-b)thiazole, 2, 3, 5, 6-tetrahydro-6-phenyl-,
monohydrochloride", "imidazo(2, 1-b)thiazole, 2, 3, 5, 6-tetrahydro-6-phenyl-,
monohydrochloride", "L-tetramisole hydrochloride", "L-tetramisole hydrochloride",
"imidazo(2, 1-beta)thiazole monohydrochloride", NSC-177023, KW-2-LE-T, KW-2-LE-T, "2, 3,
5, 6-tetrahydro-6-phenylimidazo(2, 1-b)thiazole hydrochloride", "2, 3, 5, 6-tetrahydro-6-
phenylimidazo(2, 1-b)thiazole hydrochloride", Tramisol, Tramisole, Worm-Check, Lev,
Levomysol, Nemicide, Niratic, Niratic-Puron, hydrochloride, "R-12, 564", "R-12, 564",
"Citarin L", Decaris, "Ripercol L", Solaskil, "Stimamizol hydrochloride", "ergamisol,
Meglum", anthelmintic
Toxic if swallowed.
Toxic effects may result from the accidental ingestion of the material; animal experiments indicate that ingestion of less than 40 gram may be fatal or may produce serious damage to the health of the individual. Immunostimulants, especially when given for prolonged periods produce a range of adverse and diverse effects. In common with other immunomodulators, therapeutic use of this class of drug may exacerbate the primary underlaying disease. Hypersensitivity reactions such as fever, an influenza-like syndrome, arthralgia, muscle pain, skin rashes and cutaneous vasculitis, may occur. Central nervous system effects such as fatigue, headache, confusion, insomnia, dizziness, excitation and convulsions have been reported. Other side- effects include haematological abnormalities such as agranulocytosis, leukopenia and thrombocytopenia and gastrointestinal disturbances, such as abnormal taste in the mouth.
Although the material is not thought to be an irritant, direct contact with the eye may produce transient discomfort characterized by tearing or conjunctival redness (as with windburn).
The material is not thought to produce adverse health effects or skin irritation following contact (as classified using animal models). Nevertheless, good hygiene practice requires that exposure be kept to a minimum and that suitable gloves be used in an occupational setting. Sensitization may result in allergic dermatitis responses includingrash, itching, hives or swelling of extremities.
The material is not thought to produce adverse health effects or irritation of the respiratory tract (as classified using animal models). Nevertheless, good hygiene practice requires that exposure be kept to a minimum and that suitable control measures be used in an occupational setting. Persons with impaired respiratory function, airway diseases and conditions such as emphysema or chronic bronchitis, may incur further disability if excessive concentrations of particulate are inhaled.
Principal routes of exposure are by accidental skin and eye contact andinhalation of generated dusts. No human exposure data available. For this reason health effects described are based on experience with chemically related materials. As with any chemical product, contact with unprotected bare skin; inhalation of vapor, mist or dust in work place atmosphere; or ingestion in any form, should be avoided by observing good occupational work practice.