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HACH HGEX 6 COMPLEXING REAGENT MSDS报告[下载][中文版]

Section 1 - CHEMICAL PRODUCT AND COMPANY IDENTIFICATION

PRODUCT NAME

HACH HGEX 6 COMPLEXING REAGENT

NFPA

Flammability 1
Toxicity 2
Body Contact 2
Reactivity 1
Chronic 2
SCALE: Min/Nil=0 Low=1 Moderate=2 High=3 Extreme=4

PRODUCT USE

Used for the determination of mercury.

Section 2 - HAZARDS IDENTIFICATION

CANADIAN WHMIS SYMBOLS

EMERGENCY OVERVIEW

RISK

POTENTIAL HEALTH EFFECTS

ACUTE HEALTH EFFECTS

SWALLOWED

  Accidental ingestion of the material may be damaging to the health of the individual.  The material may bind to the N-methyl-D-aspartate (NMDA) neuroreceptor. The NMDA receptor is an ionotropic glutamate receptor found on post-synaptic neurons and is a membrane channel that regulates the flow of sodium and calcium ions, flowing into the neuron, while potassium ions flow out. The NMDA receptor, therefore, tightly regulates "ion channel conductance". NMDA agonists (receptor activators), such as the glutamates, can, however, be highly toxic to the neuron. Excessive amounts of glutamate or its congeners, can be highly toxic to neurons and may contribute to neuron damage/death in stroke, epilepsy and neurodegenerative diseases. The decreased supply of oxygen (hypoxia) in stroke has been shown to result in excess glutamate release.Overactivation by glutamates, other excitatory amino-acids (EAAs) such as the cysteines and homocysteines, and its congeners (excitotoxins), causes an excessive influx of calcium, into neurons, triggering nervous tissue damage. Glutamate is the major excitatory neurotransmitter in the central nervous system. When concentrations of glutamate and excitotoxins rise above a certain level, in the extracellular fluid, the neuron begins to fire abnormally. At higher concentrations, the cells of the neuron undergo a specialised process of delayed cell death known as excitotoxicity. Although the effects of excitotoxins are generally not dramatic, certain individuals may be especially sensitive and may develop severe symptoms as a result of cardiac irritability.Excess calcium can activate pathways that are potentially harmful to the cell. For example, kinases, phospholipase A2, calpains, NO synthase, endonucleases and other enzymes can be activated. Phospholipase A2 stimulates arachidonic acid production while NO synthase produces nitric oxide. The production of both species ultimately results in free radical damage. Calpain activation may cause breakdown of the cytoskeleton and also contributes to free radical production and lipid peroxidation. Endonucleases damage neuronal DNA, as do free radicals. In addition, high internal calcium ion concentrations create large osmotic forces that drive water into the cell causing swelling and possibly, rupture. Rupture, in turn, causes the release of even more glutamate, inducing excitotoxicity in neighbouring cells. When brain cells are injured, they also release large amounts of glutamate from surrounding astrocytes and this glutamate can produce further damage in adjacent normal neuronal cells. This appears to be the case in strokes, seizures and brain trauma.Activation of calcium-dependent enzymes is thought to produce changes in neuronal function that are long-lasting, persisting for weeks or months; it has been suggested that such activation is responsible for memory. Blockade (antagonism) of the receptor by several chemical agents produces amnesia in laboratory animals.NMDA antagonists have been used as neuroprotective agents counteracting the effects of overactivation of the receptor; however such antagonists may also be harmful, at high doses, as the neuron also needs calcium for normal function. Very high doses may produce irreversible damage (including the psychomimetic effects caused by PCP -"angel dust"- abuse). Certain NMDA antagonists (notably those used to produce anaesthesis) induce arousal and even seizures. This class of drug has also produced a model psychosis indistinguishable from schizophrenia.Large doses of calcium channel blocking agents may produce nausea, weakness, dizziness, drowsiness, confusion and slurred speech. Marked and prolonged hypotension and bradycardia may result from second or third degree atrioventricular block, decreased cardiac output and junctional rhythms; death may ensue.Certain NMDA receptor antagonists may produce lightheadedness, ataxia, mood elevation and muscle incoordination. Side-effects of uptake of these antagonists (such as the isoxazole derivative, ibotenic acid, isolated from hallucinogenic mushrooms), by neurones, include dizziness, ataxia, euphoria, muscle twitches, and initial psychic stimulations followed by dream-filled sleep. More severe ingestions may produce visual disturbances, fever, confusion, myoclonus, mydriasis, seizures and coma. Residual headache may persist for several days. Ibotenic acid binds to NMDA neurotransmitter and inhibits (antagonises) its action. The congener muscimol (also isolated from mushrooms) which is structurally related to ibotenic acid and glutamic acid,  by contrast, binds to another neuroreceptor, the so-called GABA receptor. This receptor, when activated inhibits the firing of some central neurones by causing influx of anions (e.g. chloride) into the cell. Muscimol is a GABA receptor agonist and produces a similar effect and almost identical clinical outcome to that of ibotenic acid. Systemic administration of ibotenic acid and muscimol to laboratory animals produces central inhibition of motor activity with little change to peripheral autonomic activity. Both compounds induce EEG changes in cats, rabbits and rats and thus within the central nervous system both compounds behave as false inhibitory neurotransmitters.There are at least five different NMDA receptor sites that determine whether or not the channel opens. Two important ligands, glutamate and glycine (both amino-acids), are required to bind their respective NMDA sites for the channel to open. At low micromolar concentrations, polyamines, such as dopamine or cholinergic agents (binding to polyamine sites), increase the probability that glutamate and glycine will open the channel; high concentrations of polyamine, in contrast, produce the reverse effect. Two other regulatory ions, magnesium and zinc inhibit the action of amino- acids by binding to sites in the inner pore region of the NMDA channel.  

EYE

  There is some evidence that material may produce eye irritation in some persons and produce eye damage 24 hours or more after instillation. Moderate inflammation may be expected with redness; conjunctivitis may occur with prolonged exposure.  

SKIN

  There is some evidence to suggest that the material may cause mild but significant inflammation of the skin either following direct contact or after a delay of some time. Repeated exposure can cause contact dermatitis which is characterized by redness, swelling and blistering.  

INHALED

  There is some evidence to suggest that this material, if inhaled, can irritate the throat and lungs of some persons.  Persons with impaired respiratory function, airway diseases and conditions such as emphysema or chronic bronchitis, may incur further disability if excessive concentrations of particulate are inhaled.  Not normally a hazard due to non-volatile nature of product.  

CHRONIC HEALTH EFFECTS

  Limited evidence suggests that repeated or long-term occupational exposure may produce cumulative health effects involving organs or biochemical systems.  Long term exposure to high dust concentrations may cause changes in lung function i.e. pneumoconiosis; caused by particles less than 0.5 micron penetrating and remaining in the lung. Prime symptom is breathlessness; lung shadows show on X-ray.  
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